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荜橙茄挥发油对罗通定的经皮促渗作用(PDF)

《云南中医学院学报》[ISSN:1000-2723/CN:53-1048/R]

期数:
2011年02期
页码:
13-0
栏目:
实验研究
出版日期:
2011-04-01

文章信息/Info

Title:
Enhancing Effect of Volatile Oil of Fructus Litseae on Permeation of Rotundine in Vitro
作者:
崔利利马云淑△汉会勋
(云南中医学院中药学院,云南昆明650500)
Author(s):
CUI Li-liMA Yun-shu HAN Hui-xun
1.College of Chinese Traditional Medicine, Yunnan University of
关键词:
罗通定荜橙茄油累积渗透量
Keywords:
rotundinevolatile oils of fructus litseaeaccumulative penetration amount
分类号:
R285.5
DOI:
-
文献标识码:
A
摘要:
[摘要]目的:研究荜橙茄挥发油对罗通定的经皮促渗作用。方法:采用改良的Franz扩散池进行小鼠体外经皮渗透实验。以HPLC测定罗通定的累积渗透量,考察1%,3%,5%,7%荜橙茄挥发油对罗通定的促渗作用。结果: 5%,7%荜澄茄挥发油对罗通定具有促渗作用, 5%,7%荜澄茄油对罗通定的8h累积渗透量(Q8,mg/cm2)依次是5.7839,6.3837,4h的增渗倍数是1.10,1.20倍。结论:7%荜澄茄油对罗通定的促渗效果最好。
Abstract:
Traditional Chinese Medicine, Kunming Yunnan, 650200 China)Objective:To study the effect of volatile oil of Fructus Litseae(FL) on the permeation of Rotundine in vitro.Methods:A test of penetration through rat skin was conducted by using an improved Franz diffusion cell,the enhancing effect of 1%,3%,5%,7% volatile oil of FL on percutaneous permeation of Rotundine was investigated.The accumulative penetration amount of Rotundine was determined by HPLC.Results:5%,7% volatile oils of FL had enhancing effect on Rotundine permeation.The average cumulative doses of Rotundine for 8 hours (Q8, mg/cm2) of 5%,7% volatile oil of FL were 5.7839,6.3837,the enhancement ratios of 4 hours were 1.10,1.20.Conclusion:7% volatile oil of FL had the best effect of percutaneous permeation enhancing on Rotundine.

参考文献/References

[1]赵巧玲.罗通定缓释片的研究[M].军事医学科学院学报,2005,16(3):1-2.
[2]李艳杰.荜澄茄、干姜、辛夷挥发油对雪上一枝蒿总碱体外经皮渗透的影响[J].中国新药杂志,2008,17(4):310-313.
[3]李艳杰.荜澄茄等3种挥发油对乌头碱经皮渗透的影响[J].新型给药系统的研究与应用,335-342.

备注/Memo

备注/Memo:
基金项目:云南省科技计划项目(NO:2008CD152);国家自然科学基金项目(NO:30960517)收稿日期:2010—08—31修回日期:2010—12—02作者简介:崔利利(1985),女,陕西咸阳人。硕士研究生在读,主要从事中药药剂学的研究。△通讯作者:马云淑,Tel:(0871)5918204,E-mail:yunshuma2@126.com
更新日期/Last Update: 2011-06-22