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|本期目录/Table of Contents|

白及多糖对胃溃疡大鼠防治作用的实验研究(PDF)

《云南中医学院学报》[ISSN:1000-2723/CN:53-1048/R]

期数:
2012年01期
页码:
30-32
栏目:
实验研究
出版日期:
2012-02-29

文章信息/Info

Title:
The Therapeutic Effects of Polysaccharides from Bletilla Striata on Gastric Ulcer Rats
作者:
吕小波黄春球武正才杨东加邓林
云南植物药业有限公司,云南昆明650109
Author(s):
LV Xiao-bo HUANG Chun-qiu WU Zheng-cai YANG Dong-jiaDEN Lin
Yunnan Phytopharmaceutical CO.,LTD,Kunming Yunnan 650109,China
关键词:
胃溃疡溃疡指数白及多糖
Keywords:
gastric ulcerulcer indexBSP
分类号:
R2856
DOI:
-
文献标识码:
A
摘要:
目的:观察白及多糖的抗溃疡作用。方法:采用幽门结扎法、乙酸烧灼法、乙醇损伤法制备大鼠消化性溃疡模型。将实验大鼠随机分成6组,即假手术组、模型组、西咪替丁组及白及多糖高、中、低3个剂量组。阳性组大鼠灌胃给予西咪替丁01g/kg,白及多糖高、中、低剂量组大鼠灌胃给予白及多糖400,200及100mg/kg,假手术组、模型组灌胃给予等量生理盐水。按Guth标准记分判定溃疡指数并计算溃疡抑制率。结果:白及多糖对胃溃疡有明显的抑制作用,可促进溃疡大鼠的溃疡愈合,并呈一定的量效关系。
Abstract:
Objective: To study the therapeutic effects of polysaccharides from Bletilla Striata (BSP) on gastric ulcer rats. Methods: The models of gastric ulcer were established by pylorus-ligation, acitic-acid-firing and alcohol-damage. Experimental SD rats were randomly divided in 6 groups. Each group rats started to be administrated as fellows. Positive control group received 01g/kg Cimetidine (ig). High, middle and low dose BSP groups received 80, 40 and 20mg/kg BSP (ig). Sham operation group and negative model group received isovolumic normal sodium (ig). According to Guth-criterion, the ulcer index was determined and the inhibition ratio were calculated. Results: Compared with the model group, BSP inhibited gastric ulcer significantly,and promoted healing of gastric ulcer.

参考文献/References

[1]王军,王春宏,任晓玲,等.白芨胶的临床应用[J]. 中国医院药学杂志,2004,24(9):556-557.
[2]徐叔云.药理实验方法学:3版[M].北京:人民卫生出版社,2003:1331.
[3]林吉,荣向路,黄萍,等.胃肠舒胶囊抗实验性胃溃疡作用的研究[J]. 中药新药与临床药理,2005,7,16(4):256-259.
[4]瞿春莹,李定国,汪余勤,等.壳聚糖对胃溃疡大鼠血清中MDA、SOD及GSH-PX的影响[J]. 上海医药,2008,29(5):219-222.
[5] 叶木荣, 李锐, 廖雪珍,等.仲景胃灵胶囊抗胃溃疡作用研究[J]. 中成药,2002,24(9):692-694.
[6] 林吉,荣向路,黄萍,等.胃肠舒胶囊抗实验性胃溃疡作用的研究[J]. 中药新药与临床药理,2005,7,16(4):256-259.

备注/Memo

备注/Memo:
收稿日期:2011—07—08修回日期:2011—10—18 作者简介:吕小波(1979~),男,云南曲靖人,工程师,主要从事新药药理及药效学研究。
更新日期/Last Update: 2012-02-29