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|本期目录/Table of Contents|

早期糖尿病肾病痰湿证与生长转化因子、内皮素等相关性的研究(PDF)

《云南中医学院学报》[ISSN:1000-2723/CN:53-1048/R]

期数:
2014年01期
页码:
60-62,85
栏目:
临床研究
出版日期:
2014-02-25

文章信息/Info

Title:
Study on Relationship between Phlegm-damp Syndrome of the Early-stage DN Patients and TGF-β、ET
作者:
丁曦
浙江中医药大学第一附属医院,杭州浙江 310009
Author(s):
DING Xi
The First Affiliated Hospital of Zhejiang Chinese Medicine University, Hangzhou 310000, China
关键词:
糖尿病肾病 TGF-β 内皮素 中医痰湿证
Keywords:
diabetic nephropathy transforming growth factorβ endothelin TCM phlegm syndrome
分类号:
R255.4
DOI:
-
文献标识码:
A
摘要:
目的从血糖、血压、血脂,以及血浆生长转化因子(TGF-β)、内皮素(ET)这4个角度,观察早期糖尿病肾病(DN)痰湿证与非痰湿证患者、糖尿病(DM)无血管病变患者之间的区别,研究这些因素与中医痰湿辨证的相关性。方法选择早期DN患者95例,其中痰湿证组49人,非痰湿证组46人,另设50例DM患者为对照组。对以上各组的高血压分级、糖化血红蛋白(HbA1c)、空腹血糖(FPG)、甘油三酯(TG)、胆固醇(TC),以及血浆TGF-β、ET水平进行比较。结果相较非痰湿证DN患者,高血压、血脂紊乱的现象在痰湿证患者中更普遍;血浆ET水平明显增高,差异具有显著统计学意义(P<0.01)。结论高血压、血脂紊乱可能与中医痰湿辨证有关;ET水平有可能成为判断DN痰湿证的理想指标。
Abstract:
Objective To study the difference between the DM patients and the early-stage DN patients and the difference between the Phlegm-damp syndrome and non-Phlegm-damp syndrome patients, 4 factors including blood glucose、blood pressure、blood lipid、blood plasma TGF-β、ET were measured. Methods 95 early-stage DN patients were involved:49 patients were involved in the Phlegm-damp syndrome group, while the other 46 patients were involved in the non-Phlegm-damp syndrome group. Another 50 diabetes patients without vascular disease were chosen as normal group. We compared the blood pressure、FPG、TG、TC and TGF-β、ET of the above groups. Results Compared with DN non-Phlegm-damp syndrome group, hypertension、lipid metabolism disorder were more common in the Phlegm-damp syndrome group;the ET level in the DN Phlegm-damp syndrome group was obviously higher than that in the non-Phlegm-damp syndrome group, and the difference was statistically significant(P<0.01). Conclusion Hypertension、lipid metabolism disorder may connect with the TCM Phlegm-damp differentiation;The ET level might be a sensitive and ideal factor to differentiate the Phlegm-damp syndrome.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期: 2013 - 10 - 23 作者简介: 丁曦(1985-),女,浙江绍兴人,住院医师,研究方向:中西医结合内分泌。
更新日期/Last Update: 2014-03-10