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热瘀散对大肠湿热型溃疡性结肠炎患者外周血TNF-α、CRP的影响(PDF)

《云南中医学院学报》[ISSN:1000-2723/CN:53-1048/R]

期数:
2014年06期
页码:
42-44
栏目:
临床研究
出版日期:
2014-12-25

文章信息/Info

Title:
Effects of Reyusan on TNF-α、CRP in Patients with Ulcerative Colitis of Damp Heat in the Large Intestine Stagnation Type
作者:
唐小琴1王翼洲2杨辉2
1. 安徽中医药大学,安徽合肥 230031;2. 安徽中医药大学第一附属医院,安徽合肥 230031
Author(s):
TANG Xiao-qin1 WANG Yi-zhou2 YANG Hui2
1. Anhui University of Chinese Medicine, Hefei 230031, China; 2. The First Affiliated Hospital of Anhui University of Chinese, Hefei 230031, China
关键词:
热瘀散 美沙拉嗪 溃疡性结肠炎 大肠湿热型 TNF-α CRP
Keywords:
reyusan etiasa ulcerative colitis damp-heat type TNF-α CRP
分类号:
R256.34
DOI:
-
文献标识码:
A
摘要:
目的观察比较热瘀散和美沙拉嗪对大肠湿热型溃疡性结肠炎的治疗效率和对血清中TNF-α和CRP的调节作用。方法将50例大肠湿热证患者随机分为治疗组和对照组,比较2组治疗前后症状改善情况,并按病情轻重分组检测治疗前后外周血中TNF-α、CRP的含量,比较2组不同病情程度患者治疗前后血清中TNF-α、CRP水平变化。结果治疗组和对照组总有效率分别为92%、72%,2组治疗效率差异有统计学意义(P<0.05);治疗前2组轻度和轻度、中度和中度患者血清中TNF-α、CRP比较差异无统计学意义(P>0.05),2组的轻、中度患者治疗前后的TNF-α比较,差异有统计学意义(P<0.05,P<0.01),但热瘀散下调TNF-α水平效果优于美沙拉嗪;2组重度患者治疗前后差异无统计学意义(P>0.05);2组相同病情程度患者之间比较治疗前后的CRP水平,差异均有统计学意义(P<0.05),热瘀散下调幅度优于美沙拉嗪。结论热瘀散、美沙拉嗪对轻度和中度大肠湿热型溃疡性结肠炎疗效确切,但热瘀散疗效更显著;热瘀散较美沙拉嗪能明显下调患者血清中TNF-α、CRP水平。
Abstract:
Objective To observe the effect of Reyusan and Etiasa in treating Ulcerative Colitis of damp heat in the large intestine stagnation type, and to investigate Reyusan on the mechanism whether Ulcerative Colitis treated by lowering TNF-αand CRP. Methods The patients of active Ulcerative Colitis were randomly divided into treatment group and control group(Mesalazine only), compared two groups of symptom effects and main symptoms scores, and grouped by severity of serum before and after treatment of TNF-α, CRP concentrations. Results The total effective rate of treatment group was up to 92%, the control group was 72%(P<0.05); there was no significant difference between the two groups without medicines(P>0.05); after taking pills, the serum levels of TNF-α and CRP in patients with mild to moderate, were significantly lower in treatment group than those in the control group(P<0.05, P<0.01), but no significant differences in patients with severe(P>0.05); there was a significant difference before and after treatment of CRP(P<0.05). Conclusion The treatment group had better effect than control group in syndrome, Reyusan plays an important role in lowering the serum levels of TNF-αand CRP, the reduction in TNF-αand CRP are greater than Etiasa.

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备注/Memo

备注/Memo:
基金项目: 安徽中医学院青年科学研究基金项目(2012qn029) 收稿日期: 2014 -11 - 13 作者简介: 唐小琴(1988-),女,安徽安庆人,在读硕士研究生,研究方向:中医临床。 △通信作者:王翼洲,E-mail:1285903087@qq.com.
更新日期/Last Update: 2014-12-20