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银芷肛肠熏洗剂对痔组织细胞因子VEGF、CD68及MMP9的影响(PDF)

《云南中医学院学报》[ISSN:1000-2723/CN:53-1048/R]

期数:
2015年03期
页码:
43-46
栏目:
临床研究
出版日期:
2015-06-14

文章信息/Info

Title:
The Effect of YinZhi Anorectal Smoked Lotion Acting on the Hemorrhoid TissueCytokines Factor VEGF、CD68 and MMP9
作者:
杨阳宫毅马建国
云南中医学院第一附属医院,云南 昆明 650021
Author(s):
YANG Yang GONG Yi△ MA Jianguo
The No. 1 Affiliated Hospital of Yunnan University of TCM, Kunming 650021, China
关键词:
银芷肛肠熏洗剂 痔组织 细胞因子 血管内皮生长因子 CD68 基质金属蛋白酶9
Keywords:
YinZhi anorectal smoked lotion hemorrhoidal tissue cytokines factor VEGF CD68 MMP9
分类号:
R285.6
DOI:
-
文献标识码:
A
摘要:
目的〓观察银芷肛肠熏洗剂对痔组织VEGF、CD68、MMP9的影响。方法〓选取痔急性发作期患者40例,随机分为治疗组和对照组各20例。治疗组予银芷肛肠熏洗剂,对照组予金玄痔科熏洗散,肛门局部熏洗连续治疗后7d,取痔组织进行免疫组化染色检查,并与未用药直接手术痔患者(空白组)的组织进行对比,观察药物对痔组织VEGF、CD68、MMP9的影响。结果〓给药后银芷肛肠熏洗剂治疗组及金玄痔科熏洗散对照组抑制VEGF、CD68、MMP9表达的作用均优于空白组(P<0.01);银芷肛肠熏洗剂抑制VEGF、CD68、MMP9的作用优于金玄痔科熏洗散对照组(P<0.01/0.05)。结论〓银芷肛肠熏洗剂能抑制痔组织VEGF、CD68、MMP9的表达,其对痔的治疗作用可能与抑制VEGF、CD68、MMP9表达有关。
Abstract:
Objective To observe effect of YinZhi anorectal smoked lotion acting on the hemorrhoid tissue cytokines factor VEGF、CD68 and MMP9. Methods Selected 40 cases of acute episode of hemorrhoid patients were randomly divided into 20 patients in each treatment group and the control group. The treatment group were cured with YinZhi anorectal smoked lotion and the control group were cured with Ma Ying-Long Jin Xuan hemorrhoid washing powder, All two group were fumigated partialy on anal after 7 consecutive days. The hemorrhoid tissue gotten from patients compare with that were cured through surgery directly without medication by immunohistochemical staining examination. Observe the effect of medication on hemorrhoid tissue cytokines factor VEGF、 CD68 and MMP9. Results After medical treatment, YinZhi anorectal smoked lotion treatment group and Ma Ying-Long Jin Xuan hemorrhoid washing powder control group is better than blank group about inhibiting VEGF, CD68, MMP9 expression(P<0.01); YinZhi anorectal smoked lotion treatment group is better than Ma Ying-Long Jin Xuan hemorrhoid washing powder control group(P<0.01/0.05). Conclusion YinZhi anorectal smoked lotion inhibits expression of hemorrhoidal tissue cytokines factor VEGF、CD68 and MMP9. The therapeutical effect of YinZhi anorectal smoked lotion acting on hemorrhoidal tissue is possibly related with expression of inhibiting VEGF, CD68, MMP9.

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备注/Memo

备注/Memo:
* 基金项目: 云南省教育厅科学研究基金重点项目(2012Z003) 收稿日期: 2015 - 03 - 30 作者简介: 杨阳(1979-),女,云南瑞丽人,硕士,主治医师,主要从事肛肠疾病的诊治和研究工作。△通信作者:宫毅,E-mail:gongyi1797@126.com
更新日期/Last Update: 2015-06-15