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参芪强心胶囊对慢性心力衰竭患者心功能及细胞因子的影响(PDF)

《云南中医学院学报》[ISSN:1000-2723/CN:53-1048/R]

期数:
2015年03期
页码:
47-50
栏目:
临床研究
出版日期:
2015-06-14

文章信息/Info

Title:
The Effect of Shenqi Qiangxin Capsule on Heart Function andSerum Cytokines in Patients with Chronic Heart Failure
作者:
任印新1戴小华2花继平1张凤1
1. 安徽省淮北市中医院,安徽 淮北 235000;2. 安徽中医药大学第一附属医院,安徽 合肥 230038
Author(s):
REN Yinxin1 DAI Xiaohua2 HUA Jiping1 ZHANG Feng1
1. Huaibei Traditional Chinese Medical Hospital, Huaibei 235000, China;2. The First Affiliated Hospital of Anhui College of Traditional Chinese Medicine, Hefei 230038, China
关键词:
参芪强心胶囊 心功能 细胞因子 心力衰竭 肿瘤坏死因子 血浆N端前脑钠肽
Keywords:
Shenqi Qiangxin capsule heart function serum cytokines chronic heart failure TNF-α NT-proBNP
分类号:
R285.6
DOI:
-
文献标识码:
A
摘要:
目的〓观察参芪强心胶囊对慢性心力衰竭(CHF)患者心功能及血浆N端前脑钠肽(NT-proBNP)与肿瘤坏死因子(TNF-α)水平的影响。方法〓把80例心衰患者随机分为对照组、治疗组。对照组常规抗心力衰竭治疗,治疗组加服参芪强心胶囊,2组疗程均为4周。观察两组临床疗效、左室收缩末期容积(LVESV),左室舒张末期容积(LVEDV)、左室射血分数(LVEF),检测治疗前后血浆NT-proBNP、TNF-α水平。结果〓治疗组加用参芪强心胶囊后临床症状、左室收缩末期容积(LVESV),左室舒张末期容积(LVEDV)、左室射血分数(LVEF)、血浆N端前脑钠肽(NT-proBNP)与肿瘤坏死因子(TNF-α)比治疗前明显改善,且明显优于对照组,并有显著性差异(P<0.05)。对照组治疗后临床疗效、左室收缩末期容积(LVESV),左室舒张末期容积(LVEDV)、左室射血分数(LVEF)、血浆N端前脑钠肽(NT-proBNP)与肿瘤坏死因子(TNF-α)也有明显改善(P<0.05)。结论〓参芪强心胶囊治疗心衰能改善心衰患者临床疗效并降低左室收缩末期容积(LVESV),左室舒张末期容积(LVEDV)、血浆N端前脑钠肽(NT-proBNP)与肿瘤坏死因子(TNF-α)水平,提高心衰患者左室射血分数(LVEF),改善左室功能。
Abstract:
Objective To investigate the effect of Shenqi Qiangxin Capsule on Heart Function and Serum N-terminal Pro-Brain Natriuretic Peptide Tumor Necrosis Factor-α in patients with chronic heart failure. Methods 80 patients were divided into the randomly treatment group and the control group. Both groups were treated with regular treatment for 4 weeks. Simultaneously the Shenqiqiangxin capsule was added into the treatment group. We observe the changes of Clinical Efficacy、LVESV、LVEDV、LVEF、NT-proBNP and TNF-α in 80 cases before and after therapy. Results Clinical Efficacy、LVESV、LVEDV、LVEF、NT-proBNP and TNF-α were promoted after therapy in the two groups, the deference of reatment group was obvious than control group. Conclusion Shenqi Qiangxin capsule can improve the levels of LVESV、LVEDV、NT-proBNP and TNF-α in patients with chronic heart failure and improve clinical efficacy, inceased LVEF, improvement of left ventricular function.

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备注/Memo

备注/Memo:
* 基金项目: 安徽省卫计委中医药科研课题(2014zy70) 收稿日期: 2015 - 04 - 16 作者简介: 任印新(1976-),男,安徽淮北人,主治中医师,从事中医药防治心血管疾病。
更新日期/Last Update: 2015-06-15