我们的网站为什么显示成这样?

可能因为您的浏览器不支持样式,您可以更新您的浏览器到最新版本,以获取对此功能的支持,访问下面的网站,获取关于浏览器的信息:

|本期目录/Table of Contents|

益肺宣肺降浊胶囊治疗轻中度血管性痴呆的临床疗效观察(PDF)

《云南中医学院学报》[ISSN:1000-2723/CN:53-1048/R]

期数:
2015年03期
页码:
51-54
栏目:
临床研究
出版日期:
2015-06-14

文章信息/Info

Title:
Observation of the Clinical Efficacy on Yifei Xuanfei Jiangzhuo Capsule in the Treatment ofMild-to-moderate Vascular Dementia
作者:
王晋平1李伟茜2张海燕2周路1姜薇1唐农2
1. 广西中医药大学第一附属医院,广西 南宁 530023;2. 广西中医药大学,广西 南宁 530001
Author(s):
WANG Jinping1 LI Weiqian2 ZHANG Haiyan2 ZHOU Lu1 JIANG Wei1 TANG Nong2
1. The First Affiliated Hospital of Guangxi Uninversity of Traditional Chinese Medicine, Nanning 530023, China;2. Guangxi Uninversity of Traditional Chinese Medicine, NanNing 530001, Chin
关键词:
益肺宣肺降浊胶囊 轻中度 血管性痴呆 随机对照 临床观察
Keywords:
Yifei Xuanfei Jiangzhuo Capsule mild-to-moderate vascular dementia randomized controlled clinical observation
分类号:
R256.2
DOI:
-
文献标识码:
A
摘要:
目的〓观察益肺宣肺降浊胶囊治疗轻中度血管性痴呆(VD)的临床疗效及安全性。方法〓采用随机双盲对照试验的设计方法,将80例患者分为益肺宣肺降浊胶囊治疗组(治疗组,40例)和吡拉西坦胶囊对照组(对照组,40例),观察治疗前后两组患者中医证候疗效、中医证候积分(SDSVD)、洛文斯顿作业疗法评定(LOTCA评定)、日常生活活动能力量表(ADL)的变化以及该药物的安全性。结果〓治疗后治疗组中医证候疗效改善优于对照组(P<0.05);治疗后2组患者SDSVD、LOTCA评定及ADL变化均较治疗前明显改善(P<0.05),治疗组较对照组改善更为明显(P<0.05),且无明显不良反应。结论〓益肺宣肺降浊胶囊能有效地改善VD患者的SDSVD、LOTCA评定及ADL,有肯定的临床疗效,且安全可靠,值得临床推广应用及进一步深化研究。
Abstract:
Objective Observation of the clinical therapeutic effect of Yifei Xuanfei Jiangzhuo Capsule on mild-to-moderate vascular dementia to explore its the degree of reaction of chemotherapy. Methods Eighty patients with mild-to-moderate vascular dementia were randomly divided into treatment group and control group with randomized-double blind and controlled design method, each group for 40 cases, respectively. The treatment group was accepted Yifei Xuanfei Jiangzhuo Capsule, while the control group was accepted Piracetam by oral. The changes such as the curative effect of TCM syndrome, The syndroms integral of TCM symptom(SDSVD), Loewenstein Occupational Therapy Cognitive Assessment(LOTCA), The daily living ability(ADL), and The safety of the drug were observed. Results The curative effect of TCM syndrome, SDSVD、 LOTCA, and ADL in 2 groups above were both signi cantly higher than those before treatment(P<0.05), with the treatment group being more obvious than the control group(P<0.05). Conclusion Yifei Xuanfei Jiangzhuo Capsule could effectively improve the SDSVD、 LOTCA, and the curative effect of TCM syndrome on patients with mild-to-moderate vascular dementia, It obtains definite curative effect, and deserves to be spread and is studied further in the clinic.

参考文献/References

[1] Brayne C, Stephan BC, Matthews FE. A European perspective on population studies of dementia[J]. Alzheimers Dement,2011,7(1):3-9.
[2] Zhang ZX, Zahner GE, Roman GC, et al. Dementia subtypes in China: prevalence in Beijing, Xian, Shanghai, and Chengdu[J]. Arch Neurol,2005,62(3):447-453.
[3] 中华人民共和国卫生部.涉及人的生物医学研究伦理审查办法(试行):卫科教发〔2007〕17号〔EB/OL〕(2007-01-11). http//htwww. moh. gov. cn / mohbgt / pw10702/200804/18816.shtml.
[4] 郑筱萸. 中药新药临床研究指导原则[M]. 北京:中国医药科技出版社,2002:91-98.
[5] Zhang M Y, Katzman R, Salmon D, et al. The prevalence of dementia and Alzheimer’s disease in Shanghai, China:impact of age, gender, andeducation[J]. AnnNeurol,1990, 27(4):428-437.
[6] 燕铁斌,马超,郭友华,等. Loewenstein认知评定量表(简体中文版)的效度及信度研究[J]. 中华物理医学与康复杂志,2004,26(2):81-84.
[7] 唐农,黄立武. 对血管性痴呆从肺论治的思考[J]. 广西中医学院学报,2004,7(4):1-3.
[8] 魏录翠,唐农. 从肺的生理功能论肺与老年性痴呆的关系[J]. 江苏中医药,2010,42(8):3-4.
[9] 赵清山,李天威,王清碧,等. 应用一气周流理论探讨血管性痴呆从肺论治的机理[J]. 贵阳中医学院学报,2013,35(6):51-53.
[10] 唐农,黄立武,莫新民. 益肺宣肺降浊法对血管性痴呆大鼠海马CA1区LTP的影响[J]. 中国老年病杂志,2004,1(4):220-222.
[11] 唐农. 益肺宣肺降浊法对血管性痴呆大鼠学习记忆功能及海马长时程增强的影响[D]. 长沙:湖南中医药大学,2006.
[12] 赵清山. 血管性病呆从肺论治理论及其组方调节cAMP/PKA信号通路保护神经元细胞的作用机制研究[D]. 长沙:湖南中医药大学,2014.
[13] 赵清山,唐农,毕信亚,等. 唐农教授从肺论治血管性痴呆的经验[J]. 贵阳中医学院学报,2014,36(1):6-8.
[14] 张海燕,唐农,廖君,等. 从五脏失调论治血管性痴呆[J]. 云南中医学院学报,2013,36(2):30-32.
[15] 李英顺,李天琪,梁莎,等. 黄芪多糖对血管性痴呆大鼠学习记忆能力的影响[J]. 延边大学医学学报,2013,36(2):92-94.
[16] 石瑛,姬锋养,赵艳. 人参皂苷Rg1联合吡拉西坦治疗血管性痴呆临床观察[J]. 实用中医药杂志,2011,27(10):682-683.
[17] 周大兴,李昌煜. 石菖蒲对小鼠学习记忆的促进作用[J]. 中草药,1992,23(8):417.
[18] 王晋平,李景玉,唐农,等. 单味中药提取物对学习记忆功能影响的实验研究进展[C]. 第八届全国中西医结合神经科学术会议,2011.

备注/Memo

备注/Memo:
* 基金项目: 广西壮族自治区卫生厅中医药科技专项(GZPT13-11) 收稿日期: 2015 - 03 - 25 作者简介: 王晋平(1982-),男,山西太原人,主治医师,主要从事脑血管疾病的研究及临床工作。△通信作者:唐农,E-mail:272444523@qq.com
更新日期/Last Update: 2015-06-15