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|本期目录/Table of Contents|

胃复安穴位注射防治化疗后恶心呕吐的Meta分析(PDF)

《云南中医学院学报》[ISSN:1000-2723/CN:53-1048/R]

期数:
2015年04期
页码:
60-63
栏目:
临床研究
出版日期:
2015-07-25

文章信息/Info

Title:
Meta-analysis about Acupoint Injection of Metoclopramide to Prevent Digestive TractReaction during Chemotherapy of Malignant
作者:
谭亚纳1李红玲2赵亚君1李明玉1
1. 甘肃中医药大学,甘肃 兰州 730020;2. 甘肃省人民医院,甘肃 兰州 730000
Author(s):
TAN Yana1 LI Hongling2 ZHAO Yajun1 LI Mingyu1
1. Gansu University of Traditional Chinese Medicine, Lanzhou 730020, Chnia;2. The People’s Hospital of Gansu Province, Lanzhou 730000, Chnia
关键词:
胃复安 穴位注射 化疗 止吐 随机对照 Meta分析
Keywords:
metoclopramide acupoint injection chemotherapy antiemetic randomized controlled Meta-analysis
分类号:
R245.9
DOI:
-
文献标识码:
A
摘要:
目的评价足三里穴位注射甲氧氯普胺(胃复安)防治恶性肿瘤化疗所致恶心呕吐的效果。方法检索万方数据库、重庆维普数据库、CNKI、PubMed、CBM中关于胃复安穴位注射防治恶性肿瘤化疗所致恶心呕吐的临床文献,纳入胃复安穴位注射联合5-HT3受体拮抗剂(治疗组)与单用5-HT3受体拮抗剂(对照组)防治化疗所致恶心呕吐比较的随机对照试验(RCT)和临床对照试验(CCT),评价质量并提取有效数据,采用RevMan5.2软件进行Meta分析。结果共纳入5篇文献,共计254例患者。Meta分析显示胃复安穴位注射联合5-HT3受体拮抗剂与单用5-HT3受体拮抗剂防治化疗所致恶心呕吐的总有效率相比较,差异具有统计学意义[合并RR(固定效应模型)=6.59,95%可信区间(3.53,12.28),Z=5.93,P<0.01]。结论胃复安穴位注射联合5-HT3受体拮抗剂防治化疗所致恶心呕吐的总有效率优于单用5-HT3受体拮抗剂,故可初步认为,胃复安穴位注射联合5-HT3受体拮抗剂防治化疗所致恶心呕吐是有效的。
Abstract:
Objective To analyze the effect of acupoint injection of metoclopramide into Tsusanli as a way to prevent nausea and vomiting during chemotherapy of malignant tumor. Methods Through retrieval of clinical literature about the effect of acupoint injection of metoclopramide in preventing nausea and vomiting caused by chemotherapy of malignant tumor, which includes Wanfang Database, CNKI, Chongqing Weipu Database, PubMed, CBM, and incorporated with randomized controlled trials and clinical controlled trials in the case of prevention of nausea and vomiting caused by chemotherapy and by the means of making comparison between Treatment group where acupoint injection of metoclopramide was combined with the use of 5-HT3 receptor antagonist and Control group where only 5-HT3 receptor antagonist was used. Afterwards. the analysis of quality was carried out and effective data were extracted. which underwent Meta analysis using RevMan5.2 software. Results Incorporated with 5 literature, and 254 patients. Meta analysis indicated that in the case of prevention of nausea and vomiting caused by chemotherapy, the difference in total efficiency between acupoint injection of metoclopramide with combination of 5-HT3 receptor antagonist and sole use of 5-HT3 receptor antagonist was of statistical significance[polled random effects model(RR)=6.59, 95% confidence interval (3.53, 12.28), Z=5.93, P<0.01]. Conclusion In the case of prevention of nausea and vomiting caused by chemotherapy, the total efficiency of acupoint injection of metoclopramide with combination of 5-HT3 receptor antagonist was superior to that of the sole use of 5-HT3 receptor antagonist. Therefore, the preliminary conclusion suggests that the method of acupoint injection of metoclopramide with combination of 5-HT3 receptor antagonist is effective in preventing nausea and vomiting caused by chemotherapy.

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备注/Memo

备注/Memo:
* 基金项目: 国家自然科学研究基金(81260342);国家自然科学研究基金地区基金(30960438) 收稿日期: 2015 - 06 - 26 作者简介: 谭亚纳(1989-),女,江西吉安人,在读硕士研究生,研究方向:肿瘤内科化疗。△通信作者:李红玲,E-mail:lihongling1969@126.com
更新日期/Last Update: 2015-07-30