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健脾益肾方对血液透析患者继发性甲旁亢的疗效观察(PDF)

《云南中医学院学报》[ISSN:1000-2723/CN:53-1048/R]

期数:
2015年04期
页码:
70-72,88
栏目:
临床研究
出版日期:
2015-07-25

文章信息/Info

Title:
The Clinical Observation of Therapeutic Effect of Jianpi Yishen Decoction on HemodialysisPatients with Secondary Hyperparathyroidism
作者:
韩晓苇傅博祁爱蓉程淑碧
广州中医药大学深圳附属医院,广东 深圳 518033
Author(s):
HAN Xiaowei FU Bo QI Airong CHENG Shubi
ShenZhen Affiliated Hospital, GuangZhou University of Traditional Chinese Medicine, ShenZhen 518033, China
关键词:
血液透析 肾性骨病 PTH FGF-23 125(OH)2D3
Keywords:
hemodialysis renal osteodystrophy PTH FGF-23 125(OH)2D3
分类号:
R255.4
DOI:
-
文献标识码:
A
摘要:
目的观察健脾益肾方对改善血液透析患者继发性甲旁亢的临床疗效。方法将60例患者分为2组,其中治疗组30例采用健脾益肾方口服联合基础血液净化治疗(即每周血液透析2次,血液透析滤过1次,使用的药物包括促红细胞生成素、透析参数如血流量、透析器及透析机的型号均相同);对照组30例进行基础血液净化治疗。对2组患者的骨痛症状、瘙痒程度、PTH、Ca、P、K+、FGF-23、Leptin、1,25(OH)2D3等指标进行比较。结果治疗组患者的骨痛症状、皮肤瘙痒程度、BUN、Scr、Leptin等数值与对照组比较,明显降低,差异有统计学意义(P<0.05或P<0.01);但2组患者治疗后的PTH、Ca、P、K+、FGF-23、1,25(OH)2D3等指标比较,无统计学意义(P>0.05)。结论健脾益肾方口服联合基础血液净化治疗,能明显减轻血液透析患者骨痛程度及皮肤瘙痒症状,降低BUN、Scr、Leptin,且不影响血K+浓度;能降低PTH、Ca、P、FGF-23、1,25(OH)2D3数值,但无统计学意义。
Abstract:
Objective To observe the effect of Jianpi Yishen Decoction on hemodialysis patients with secondary hyperparathyroidism. Methods 60 patients of them were randomly divided into two groups,“treatment group of 30 cases” and “control group of 30 cases”. The treatment group was used with Jianpi Yishen Decoction oral Combined with basic hemodialysis (Twice hemodialysis and once hemodiafiltration every week, using drugs including erythropoietin, dialysis parameters such as blood flow, dialyzer and dialysis machine models were the same). The control group of 30 cases was cured with basic hemodialysis. Its index of bone pain degree,itching degree,PTH、 Ca、 P、 K+、 FGF-23、 Leptin and 1,25(OH)2D3 were compared. Results The bone pain degree and skin itching, including BUN、 Scr、 Leptin of treatment group compared with the control group were significant differences(P<0.05 or P<0.01); but the PTH, Ca, P, K+, FGF-23,1,25(OH)2D3 testings of treatment group compared with the control group, had no significant difference(P>0.05). Conclusion Jianpi Yishen Decoction Combined with basic hemodialysis treatment can obviously relieve bone pain and skin itching degree, reduce the BUN、 Scr、 Leptin values, Without affecting the blood of K+, and Can reduce PTH, Ca, P, FGF-23,1,25(OH)2D3 values, even if without statistical significance.

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备注/Memo

备注/Memo:
* 基金项目: 广东省中医药局课题(20122032) 收稿日期: 2015 - 04 - 10 作者简介: 韩晓苇(1990-),女,山东昌邑人,副主任护师,主要研究方向血液净化疗法的临床应用。
更新日期/Last Update: 2015-07-30