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|本期目录/Table of Contents|

4种常用神经病理痛动物模型的评价(PDF)

《云南中医学院学报》[ISSN:1000-2723/CN:53-1048/R]

期数:
2015年04期
页码:
92-95
栏目:
综述
出版日期:
2015-07-25

文章信息/Info

Title:
Assessment in Research on Four Animal Models of Neuropathicpain
作者:
叶佳瑜1颜思思1蒋永亮12何晓芬12杜俊英12陈利芳12方剑乔3
1. 浙江中医药大学第三临床医学院,浙江 杭州 310053;2. 浙江中医药大学附属第三医院,浙江 杭州 310005;3. 浙江中医药大学,浙江 杭州310053
Author(s):
YE Jiayu1 YAN Sisi1 JIANG Yongliang12 HE Xiaofen12 DU Junying12 CHEN Lifang12 FANG Jianqiao3
1. The Third Clinical Medical college of Zhejiang Chinese Medical University, Hangzhou 310053, China; 2. The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310053, China; 3. Zhejiang Chinese Medical University, Hangzhou 310053, China
关键词:
神经病理痛 动物模型 综述
Keywords:
neuropathicpain animal model review
分类号:
R-332
DOI:
-
文献标识码:
A
摘要:
神经病理痛动物模型是研究神经病理痛的基础,能够模拟临床神经病理痛的症状和体征,为神经病理痛的研究提供科学依据。由于神经病理痛发病机制复杂、多样,单一的模型不能完全复制全面的神经病理痛情况,因此需要各种具有临床针对性的理想的神经病理痛动物模型。本文就4种常用的神经病理痛模型进行综述,以期为神经病理痛的研究提供参考。
Abstract:
Animal models of neuropathic pain provide pivotal system for preclinical study, for the similarity to clinical neuropathic pain syndromes.However, the complex and various pathogenesis of neuropathic pain call for differential and relevant animal models of neuropathic pain. This article reviews four of the most widely used and promising new models of neuropathic pain. Chronic constriction injury model(CCI), partial spinal ligation model(PSL), and spinal nerve ligation model(SNL) represent three of the best characterized rodent models of peripheral neuropathy. While, spared nerve injury model(SNI) have been widely and recently reported. All of them are established to study the molecular mechanism of pain, especially for neurotransmitter release and signal transduction. Each model is uniquely created with distinct mechanisms, it is therefore essential to report and interpret results in the context.

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备注/Memo

备注/Memo:
* 基金项目: 国家自然科学基金(81303038) 收稿日期: 2015 - 04 - 28 作者简介: 叶佳瑜(1990-),女,浙江瑞安人,在读硕士研究生,研究方向:针刺镇痛与免疫调节的相关性研究。△通信作者:方剑乔,E-mail:fangjianqiao7532@163.com
更新日期/Last Update: 2015-07-30