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生发Ⅰ号联合局部注射糖皮质激素治疗斑秃患者秃眉的临床观察(PDF)

《云南中医学院学报》[ISSN:1000-2723/CN:53-1048/R]

期数:
2015年05期
页码:
84-86,100
栏目:
临床研究
出版日期:
2015-09-25

文章信息/Info

Title:
The Clinical Effect of Intralesional Glucocorticoid Injection in the Treatment of Alopecia Areata Patients with Eyebrow Loss Symptom
作者:
孙丹杨晓红何慧英陶茂灿鲁贤昌曹毅△
浙江中医药大学第一附属医院,浙江 杭州 310006
Author(s):
SUN Dan YANG Xiaohong HE Huiying TAO Maocan LU Xianchang CAO Yi△
The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, China
关键词:
局部注射 糖皮质激素 斑秃 秃眉
Keywords:
local injection glucocorticoid alopecia areata eyebrows loss
分类号:
R275
DOI:
-
文献标识码:
A
摘要:
目的观察生发Ⅰ号联合局部注射糖皮质激素治疗对于斑秃患者秃眉的临床疗效。方法60例伴有秃眉的斑秃患者按照就诊顺序分为治疗组20例:生发Ⅰ号胶囊(口服,5粒/次,3次/d)联合得宝松混悬液(局部注射,2周/次);对照组Ⅰ20例:得宝松混悬液(局部注射,2周/次);对照组Ⅱ20例:生发Ⅰ号胶囊(口服,5粒/次,3次/d);8周末治疗组停止局部注射疗法,继续口服生发Ⅰ号胶囊至12周末。治疗前和第2,4,8,12周末评估观察指标。结果治疗效果在各个时间段具有显著差异性(F=218.253,P<0.01);时间因素与组别因素存在交互效应:治疗组、对照组Ⅰ与对照组Ⅱ的治疗效果随着治疗时间变化逐渐改善(F=7.709,P<0.01);组间比较治疗组比对照组Ⅰ与对照组Ⅱ疗效更加显著(P<0.01),而对照组Ⅰ与对照组Ⅱ疗效比较不明显,差异不具有统计学意义(P>0.05)。结论生发Ⅰ号胶囊联用糖皮质激素局部注射治疗斑秃患者秃眉症状具有操作简单、起效快、疗效确切、不良反应停药消退等特点,适合临床推广。
Abstract:
Objective To observe the clinical effect of local injections with glucocorticoid for alopecia areata(AA) patients who with eyebrow loss. Methods 60 AA patients with eyebrow loss were divided into three groups in order of been diagnosed initially. 20 cases in the treatment group were treated with diprospan suspension localized injection biweekly and hair-promoting capsulesⅠorally taken five capsules per time and three times per day; 20 cases in the control groupⅠwere treated with diprospan suspension localized injection biweekly; 20 cases in the control groupⅡwere treated with hair-promoting capsulesⅠorally taken five capsules per time and three times per day; The injection of the glucocorticoid suspension was stopped after 8 weeks, while hair-promoting capsuleⅠwas continued to 12 weekends. The observational indicator was evaluated at baseline, 2nd weekends, 4th weekends, 8th weekends and 12th weekends after treatment. Results The difference of clinical effects showed significance as time goes on(F=218. 253, P<0.01); Time factors and group factors had interactive effects on clinical effects: the clinical effect of treatment group and control group showed gradual improvement as time goes on(F=7. 709, P<0.01); The clinical effect of treatment groups were more significant than control group(P<0.01), the difference between control groupⅠand control groupⅡ was not obvious(P>0.05). Conclusion The glucocorticoid localized injection has many characteristics with simplicity operation, quickly and precisely clinic effect, and its side effect would gradually resolved as time goes on after glucocorticoid withdrawl. Combination of glucocorticoid localized injection and hair-promoting capsulesⅠorally taken is worth to promote to treat AA patients with eyebrow loss symptom.

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备注/Memo

备注/Memo:
基金项目: 全国名老中医专家传承工作室建设项目—鲁贤昌名中医工作室(国中医药人教涵[2012]149号) 收稿日期: 2015 - 06 - 14 作者简介: 孙丹(1988-),女,陕西宝鸡人,在读硕士研究生,研究方向:中医药治疗皮肤病。△通信作者:曹毅,E-mail:caoyi1965@163.com
更新日期/Last Update: 2015-09-20