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|本期目录/Table of Contents|

新加达原饮治疗慢性乙型肝炎的临床研究*(PDF)

《云南中医学院学报》[ISSN:1000-2723/CN:53-1048/R]

期数:
2015年06期
页码:
61-63
栏目:
临床研究
出版日期:
2015-11-25

文章信息/Info

Title:
Clinical Research of Xinjia Dayuan Decotion on Chronic Hepatitis B
文章编号:
1000-2723(2015)06-0061-03
作者:
王礼凤1宋春蓉2曹宁1齐婧3鱼富丽3郑旭锐1惠毅1
1.陕西中医药大学基础医学院,陕西 咸阳712046;
2.陕西中医药大学第一附属医院感染科,陕西 咸阳712000;
3.陕西中医药大学第二附属医院科研部,陕西 咸阳712000
Author(s):
WANG Lifeng1SONG Chunrong2CAO Ning1QI Jing3YU Fu-li3ZHENG Xurui1HUI Yi1
1.Basic Medical College, Shanxi University of Traditional Chinese Medicine, Xianyang, 712046, China;
2.Department of Infectious Disease, the First Affiliated Hospital of Shanxi University of Traditional Chinese Medicine, Xianyang 712000, China;
关键词:
慢性乙型肝炎 新加达原饮 临床研究
Keywords:
chronic hepatitis B Xinjia Dayuan decotion clinical research
分类号:
R256.4
DOI:
-
文献标识码:
A
摘要:
目的〓观察新加达原饮治疗慢性乙型肝炎(CHB)的临床疗效。方法〓20例患者均给予新加达原饮治疗,疗程12周,比较治疗前、治疗后4、8、12周时患者肝功能,HBeAg及HBV-DNA变化情况,分析ALT、HBeAg及HBV-DNA的关系。结果〓与治疗前比较,患者ALT于治疗后8周时显著升高(P<0.01),12周时明显下降(P<0.01);HBeAg及HBV-DNA水平持续下降,治疗12周时下降最显著(P<0.01)。结论〓新加达原饮能快速降低慢性乙型肝炎患者HBeAg及HBV-DNA的水平,根据治疗后患者ALT,HBV-DNA及HBeAg变化曲线不同,推测新加达原饮抗乙型肝炎病毒的机制可能是通过激发机体免疫应答完成的。
Abstract:
Objective To observe the clinical effects of treatment of Xinjia Dayuan decotion on chronic hepatitis B. Methods 20 patients with CHB were treated with Xinjia Dayuan decotion for 12 weeks. Compared the ALT, HBeAg and HBV-DNA of patients before treatment with 4, 8, 12 weeks of treatment, and analyzed the relationship of them. Results Compared with pre-treatment, the levels of ALT were rised after treatment, significantly at week 8 treatment(P<0.01), were significantly decreased at week 12 treatment(P<0.01); The levels of HBeAg and HBV DNA were decreased after treatment, significantly decreased at week 12 treatment(P<0.01). Conclusion Xinjia Dayuan decotion could reduce the levels of HBeAg and HBV DNA in patients with CHB quickly. According to the difference on the changing track between the ALT, HBV DNA and HBeAg of patients after treatment, we speculated that the antiviral mechanism about Xinjia Dayuan decotion may be done by stimulating the body’s immune response.

参考文献/References

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备注/Memo

备注/Memo:
*基金项目:陕西省中医管理局资助项目(13-LC074)
收稿日期:2015-09-18
作者简介:王礼凤(1971-),女,陕西西安人,副教授,主要从事中医药防治慢性肝病的基础与临床研究。E-mail:lif.w@163.com
更新日期/Last Update: 2015-12-03