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清热化痰法联合西医常规治疗慢性阻塞性肺疾病疗效的Meta分析*(PDF)

《云南中医学院学报》[ISSN:1000-2723/CN:53-1048/R]

期数:
2015年06期
页码:
71-74
栏目:
临床研究
出版日期:
2015-11-25

文章信息/Info

Title:
Meta Analysis of the Efficacy on Method of Clearing Heat and Removing Phlegm Combined with Routine Western Medical Treatment for Chronic Obstructive Pulmonary Disease
文章编号:
1000-2723(2015)06-0071-04
作者:
李代深1陈斯宁2郑景辉2
1.广西中医药大学,广西 南宁 530001;
2.广西中医药大学附属瑞康医院,广西 南宁 530011
Author(s):
LI Daishen1CHEN Sining2ZHENG Jinghui2
1.Guangxi University of Chinese Medicine, Nanning 530001, China2.Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530011, China
关键词:
慢性阻塞性肺疾病 清热化痰法 Meta分析
Keywords:
chronic obstructive pulmonary disease method of clearing heat and removing phlegm Meta analysis
分类号:
R256.14
DOI:
-
文献标识码:
A
摘要:
目的〓评价清热化痰法联合西医常规治疗慢性阻塞性肺疾病的临床疗效。方法〓按Cochrane 系统评价方法,计算机检索中国医院数字图书馆的中国期刊全文数据库(CNKI)、万方数据库、维普中文期刊数据库(VIP)、PubMed数据库、Embase数据库从建库至2014年11月用清热化痰法联合西医常规治疗慢性阻塞性肺疾病临床试验的文献。按照纳入排除标准筛选文献,对文献进行评价质量,并提取资料,采用RevMan 5.2软件进行 Meta 分析。结果〓纳入 8个随机对照试验,共693例患者,其中试验组346例,对照组347例。Meta 分析结果显示:清热化痰法联合西医常规可以明显改善慢性阻塞性肺疾病的临床症状,[OR=5.36,95%Cl(2.94,9.78),(P<0.00001)];PaO2:[WMD=8.14,95%Cl(1.31,14.97),(P<0.05)]。PaCO2:[WMD=-7.33,95%Cl(-13.75,-0.92),(P<0.05)]。FEV1/FVC:[WMD=2.75,95%Cl(0.85,4.65),(P<0.05)]。结论〓清热化痰法联合西医常规治疗慢性阻塞性肺疾病有效。问题与展望:前期研究质量不高,结果存在发表偏倚;目前对疗效尚不能得出最终结论,有待于高质量的临床研究,开展更多前瞻性、大样本、多中心的随机对照试验。
Abstract:
Objective Analysis of clinical trials of clearing heat and removing phlegm combined with routine Western medical treatment in treating chronic obstructive pulmonary disease by meta analysis. Methods The randomized or semi-randomized controlled studies involving treatment of COPD with clearing heat and removing phlegm combined with routine Western medical treatment were searched and identified from CNKI, Wanfang Data, VIP, PubMed and Embase. According to Cochrane methods, two reviewers independently screened literature, assessed methodological quality, extracted data, and analysis by RevMan 5.2 software. Results A total of 8 studies, including 693 cases of patients (346 in experimental group and 347 in control group) were included, The results of Meta analysis suggest that: Clearing heat and removing phlegm combined with routine Western medical treatment can significantly improve the clinical symptoms in patients with chronic obstructive pulmonary disease[OR=5. 36, 95%Cl(2.94, 9.78), (P<0.00001)]; PaO2: [WMD=8.14, 95%Cl(1.31, 14.97), (P<0.05)]. PaCO2: [WMD=-7.33, 95%Cl(-13.75, -0.92), (P<0.05)]. FEV1/FVC:[WMD=2.75, 95%Cl(0.85, 4.65),(P<0.05)]. Conclusion Clearing heat and removing phlegm combined with routine Western medical treatment in treating chronic obstructive pulmonary disease is effective. Problem and Prospect:The results of the previous research and the trial quality are low, the experiment potential publication bias. We cannot make a final conclusion of the effectiveness based on this Meta analysis. High quality trials with large sample size and multi-center are needed to verify its clinical effects.

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备注/Memo

备注/Memo:
*基金项目:广西卫生厅重点科研课题(重2012037)
收稿日期:2015-05-11
作者简介:李代深(1988-),男,广西玉林人,在读硕士研究生,研究方向:中西医结合防治慢性阻塞性肺疾病。
更新日期/Last Update: 2015-12-03