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加味酸枣仁汤治疗阴虚火旺型焦虑性失眠障碍的临床研究(PDF)

《云南中医学院学报》[ISSN:1000-2723/CN:53-1048/R]

期数:
2016年01期
页码:
95-98
栏目:
临床研究
出版日期:
2016-02-02

文章信息/Info

Title:
Clinical Research of Jiawei Suanzaoren Decoction in the Treatment of the Syndrome ofFire Excess from Yin Deficiency of Insomnia Disorder with Anxiety
文章编号:
1000 - 2723(2016)01 - 0095 - 04
作者:
任丹丹1胡霖霖2张永华2
1. 浙江中医药大学,浙江 杭州 310053;
2. 杭州市第七人民医院,浙江 杭州 310013
Author(s):
REN Dandan1 HU Linlin2 ZHANG Yonghua2
1. Zhejiang Chinese Medical University, Hangzhou 310053, China;
2. The Seventh People’s Hospital in Hangzhou, Hangzhou 310053, China
关键词:
加味酸枣仁汤 阴虚火旺证型 焦虑性失眠障碍
Keywords:
Jiawei Suanzaoren decoction the syndrome of fire excess from yin deficiency insomnia disorder with anxiety
分类号:
R256.2
DOI:
10.19288/j.cnki.issn.1000-2723.2016.01.023
文献标识码:
A
摘要:
目的 观察加味酸枣仁汤治疗阴虚火旺型焦虑性失眠障碍的临床疗效及对IL-1家族的影响。方法 将阴虚火旺型焦虑性失眠障碍患者80例,随机分为中药组、西药组,每组40例;中药组给予加味酸枣仁汤煎剂治疗,西药组给予劳拉西泮片(罗拉)治疗,疗程均为4周;分别于治疗前、2周、4周后进行HAMA、PSQI表评定,治疗后进行临床综合疗效评估,在治疗前后采用ELISA法测定IL-1β、IL-1α、IL-1 Ra含量。结果 中药组与西药组在治疗2周、4周后HAMA、PSQI评分与治疗前比较均有所降低(P<0.01),但2组同期比较无统计学差异(P>0.05),2组治疗后的临床疗效无明显差异(P>0.05);治疗后中药组IL-1β、IL-1α含量较治疗前明显升高(P<0.01),IL-1 Ra含量较治疗前明显降低(P<0.01),治疗后西药组IL-1β、IL-1α、IL-1 Ra含量与治疗前比较差异无统计学意义,治疗前同期2组间的比较无统计学差异(P>0.05),治疗后中药组IL-1β、IL-1α含量较西药组明显升高(P<0.01),IL-1 Ra含量较西药组明显降低(P<0.01)。结论 加味酸枣仁汤是治疗阴虚火旺证型焦虑性失眠障碍的有效方剂,与西药疗效相当;加味酸枣仁汤调节睡眠的机制与增加具有促眠作用的细胞因子含量、减少具有阻断睡眠作用的细胞因子含量有关。
Abstract:
Objective To observe the clinical effect of Jiawei Suanzaoren decoction in the treatment of the syndrome of fire excess from yin deficiency of Insomnia disorder with anxiety, and the effect of IL-1 family. Methods 80 patients with the syndrome of fire excess from yin deficiency of Insomnia disorder with anxiety were randomly divided into two groups:traditional Chinese medicine group treated with Jiawei Suanzaoren decoction, western medicine group treated with Lorazepam tablets(Rolla). The course of treatment was 4 weeks, and evaluation the scores of two groups with HAMA and PSQI before and after treatment and the clinical effects after treatment. IL-1β, IL-1α, IL-1Ra was measured with enzyme linked immunosorbent assay(ELISA). Results The scores of two groups with HAMA and PSQI after treatment were lower than before treatment(P<0.01), but the contrast of scores of two groups with HAMA during the same period and clinical effects after treatment, there were not significant difference(P>0.05). IL-1β, IL-1α content of traditional Chinese medicine group after treatment were higher than before treatment(P<0.01), IL-1 Ra content after treatment were lower than before treatment(P<0.01). Compared after treatment and before treatment with IL-1β, IL-1α, IL-1 Ra content of Western medicine group was not significant difference(P>0.05). IL-1β, IL-1α, IL-1 Ra content of two groups during the same period before treatment, there were not significant difference(P>0.05). IL-1β, IL-1α, IL-1 Ra content of two groups during the same period after treatment, there were significant difference(P<0.01). IL-1β, IL-1α content of traditional Chinese medicine group were higher than Western medicine group after treatment(P<0.01), IL-1 Ra content was lower than Western medicine group after treatment(P<0.01). Conclusion Jiawei Suanzaoren decoction was effective for the treatment of Insomnia disorder with anxiety. Efficacy of two groups was similar. Jiawei Suanzaoren decoction can regulate sleep. The mechanisms is associated with Jiawei Suanzaoren decoction can increase cytokine levels that can promote the role of sleep and can decrease cytokine levels that can Block the role of sleep.

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备注/Memo

备注/Memo:
基金项目: 杭州市科技发展计划项目(20140733Q49)
作者简介: 任丹丹(1989-),女,安徽临泉人,在读硕士研究生,主要从事失眠障碍方面的研究。
通信作者:张永华,E-mail:zyh16916@163.com
更新日期/Last Update: 2016-02-28