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帕金森病中医证候与运动症状的相关性研究(PDF)

《云南中医学院学报》[ISSN:1000-2723/CN:53-1048/R]

期数:
2016年05期
页码:
65-68
栏目:
临床研究
出版日期:
2016-10-10

文章信息/Info

Title:
Research on the Correlation between Motor Symptoms of Parkinson’s Disease and TCM Syndromes
作者:
李婷1田金洲1秦斌2樊东升3刘建平4刘娜3费羽彤4李雨濛1张天清1时晶1
1.北京中医药大学东直门医院,北京 100700;2.北京医院,北京 100730;3.北京大学第三医院,北京 100191;4.北京中医药大学,北京 100029
Author(s):
LI Ting1 TIAN Jinzhou1 QIN Bin2 FAN Dongsheng3 LIU Jianping4 LIU Na3 FEI Yutong4 LI Yumeng1 ZHANG Tianqing1 SHI Jing1
1. Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China;2. Beijing Hospital, Beijing, 100700, China; 3. Peking University Third Hospital, Beijing 100080, China;4. Beijing University of Chinese Medicine, Beijing 100029, Chin
关键词:
帕金森病 中医证候 运动症状 血虚动风证
Keywords:
Parkinson’s disease TCM motor symptoms Xuexu Dongfeng syndrome
分类号:
R277.7
DOI:
10.19288/j.cnki.issn.1000-2723.2016.05.017
文献标识码:
A
摘要:
目的〓研究帕金森病中医证候与运动症状的相关性,为中医辨证治疗帕金森病提供依据。方法〓选取2015年1月1日-2016年5月31日就诊于北京中医药大学东直门医院、北京医院和北医三院的帕金森病患者178例,采用中医证候诊断量表诊断中医证候,统一帕金森病评定量表-III评价运动症状,采用二元logistic回归法分析帕金森病中医证候与运动症状的相关性。结果〓帕金森病患者运动症状与中医证候的相关性分析显示,髓减证(b=0.432,P=0.011)、肝风证(b=0.379,P=0.008)、血虚证(b=0.480,P=0.004)、气虚证(b=0.307,P=0.035)、内热证(b=0.313,P=0.024)与帕金森病震颤症状显著相关;血虚证(b=0.169,P=0.035)、气虚证(b=0.143,P=0.045)与帕金森病姿势步态异常显著相关;阴虚证(b=0.166,P=0.038)与少动显著相关。结论〓帕金森病震颤症状与中医血虚动风证、内热动风证、髓减证、气虚证显著相关;姿势步态异常与血虚证、气虚证显著相关;少动与阴虚证显著相关,故治疗宜各有侧重。
Abstract:
Objective To study the correlation between motor symptoms of Parkinson’s disease(PD) and Traditional Chinese Medicine(TCM) syndromes to provide evidence for TCM treatment. Methods 178 PD cases from Dongzhimen Hospital, Beijine Hospital and Peking University Third Hospital were included in the study. The Pattern Element Scale of PD was used for different diagnosis of TCD subtyping. The Unified Parkinson’s Disease Rating Scale-Ⅲ was used to evaluate motor symptoms of PD. The correlation between motor symptoms of PD and TCM subtyping was analyzed by binary logistic regression. Results Suijian syndrome(b=0.432, P=0.011), Ganfeng syndrome(b=0.379, P=0.008), Xuexu syndrome(b=0.480, P=0.004), Qixu syndrome(b=0.307, P=0.035) and Nei-Re syndrome(b=0.313, P=0.024)are related to tremor. Xue-Xu(b=0.169, P=0.035)syndrome and Qixu(b=0.143, P=0.045)syndrome are related to postural instability and gait difficulty. Yinxu syndrome(b=0.166, P=0.038) is related to bradykinesia. Conclusion Xuexu Dongfeng syndrome、Neire Dongfeng syndrome、Suijian syndrome and Qixu syndrome are closely related to tremor of PD. Xuexu syndrome and Qixu syndrome are closely related to postural instability and gait difficulty. Yinxu syndrome is closely related to bradykinesia. Different therapies might be used while treating different PD subtypes.

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备注/Memo

备注/Memo:
* 基金项目: 首都卫生发展科研专项基金(首发2014-1-4191);首都临床特色应用研究(Z141107002515019) 收稿日期: 2016 - 08 - 30 作者简介: 李婷(1988-),女,辽宁鞍山人,住院医师,研究方向:神经变性病的中医药防治。△通信作者:时晶,E-mail:shijing87@hotmail.com
更新日期/Last Update: 2016-10-10