我们的网站为什么显示成这样?

可能因为您的浏览器不支持样式,您可以更新您的浏览器到最新版本,以获取对此功能的支持,访问下面的网站,获取关于浏览器的信息:

|本期目录/Table of Contents|

黄芪注射液和黄芪总皂苷注射液治疗冠心病心绞痛临床疗效的系统评价(PDF)

《云南中医学院学报》[ISSN:1000-2723/CN:53-1048/R]

期数:
2017年01期
页码:
22-27
栏目:
临床研究
出版日期:
2017-02-20

文章信息/Info

Title:
Meta-analysis of Clinical Efficacy of Astragalus Injection and AstragalusTotal-saponinInjection in Patients with Angina Pectoris
作者:
王海芳1曹情雯2王娜娜1刘勤社3
1. 陕西省人民医院中心实验室,陕西 西安 710068;2. 陕西省中医医院急诊科,陕西 西安 710003;3. 西安交通大学医学部公共卫生学院,陕西 西安 710049
Author(s):
WANG Haifang1CAO Qingwen2WANG Nana1LIU Qinshe3
1. Central Lab of Shaanxi Provincial People’s Hospital, The Third Affiliated Hospital of the Medical College of Xian Jiaotong University, Xian 710068, China; 2. Shaanxi Provincial Hospital of Traditional Chinese Medicine, Xian 710003, China;3. School of Public Health, Xian Jiaotong University Health Science Center, Xian 710049, China
关键词:
黄芪注射液 黄芪总皂苷注射液 冠心病心绞痛 随机对照试验 Meta分析 系统评价
Keywords:
Astragalus injection Astragalus Total-saponin injection angina pectoris randomized controlled trial Meta-analysis systematic review
分类号:
R259
DOI:
10.19288/j.cnki.issn.1000-2723.2017.01.006
文献标识码:
A
摘要:
目的 系统评价黄芪注射液和黄芪总皂苷注射液辅助治疗冠心病心绞痛的临床疗效。方法 计算机检索相关数据库,包括PubMed、The Cochrane Library、EMbase、CBM、CNKI、VIP和WanFang Data,收集2015年12月之前的研究文献,由两位研究者根据纳入及排除标准独立筛选文献、提取信息及评价纳入文献的方法学质量,采用Rev Man 5.2软件进行Meta分析。结果 Meta分析结果显示,在改善心绞痛症状和改善心电图方面,黄芪注射液辅助西药治疗疗效优于单纯常规西药治疗,其统计结果分别为[OR=3.67,95% CI(2.42,5.56),P<0.001]和[OR=3.15,95% CI(2.26,4.41),P<0.001];黄芪总皂苷注射液与川芎嗪注射液的疗效无显著差异,其统计结果分别为[OR=1.12,95% CI(0.58,2.15),P=0.74]和[OR=1.15,95% CI(0.63,2.11),P=0.64]。以气虚血瘀证型冠心病心绞痛作为观察证型对相关研究进行分析,显示黄芪总皂苷注射液和川芎嗪注射液对中医症候的疗效相似(P=0.81)。结论 在治疗冠心病心绞痛方面,黄芪注射液和黄芪总皂苷注射液均具有显著疗效,不过,此结论仍需设计严谨的高质量临床试验进一步进行验证。
Abstract:
Objective To evaluate the clinical efficacy of Astragalus Injection and Astragalus Total-saponin Injection in Patients with angina pectoris. Methods Search the Cochrane Library, PubMed, CBM, CNKI, WanFang Data and VIP and collect information of randomized controlled trial(RCT) about the application of Astragalus Injection and Astragalus Total-saponin Sodium Chloride Injection in the treatment of Angina pectoris, building a database to retrieve the time to December, 2015. Two reviewers independently screened the literatures based on inclusion and exclusion criteria, and extracted information and evaluation methods including studies after methodology quality by use of software Rev Man 5.2.9 Meta-analysis. Results Meta-analysis showed that, compared with conventional western medicine treatment, Astragalus Injection associated with western medicine treatment could significantly improve the symptoms of angina[OR=3.67, 95% CI(2.42, 5.56), P<0.001]and the electrocardiogram[OR=3.15, 95% CI(2.26, 4.41), P<0.001]. The clinical efficacy of Astragalus Total-saponin Injection was comparative to that of Ligustrazine Sodium Chloride Injection([OR=1.12, 95% CI(0.58, 2.15), P=0.74] and [OR=1.15, 95% CI(0.63, 2.11), P=0.64], respectively). When angina patients of Qi and Blood Stasis type were analyzed separately, it was shown that Astragalus Total-saponin Injection had similar efficacy in the improvement of traditional Chinese medicine syndromes with Ligustrazine Sodium Chloride Injection(P=0.81). Conclusion Both Astragalus Injection and Astragalus Total-saponin Injection have significant effects in the treatment of angina pectoris. However, Due to the poor quality and the quantity limitation, he above conclusions still need to be verified through more large samples of high-quality RCT.

参考文献/References

[1] 刘梨,龚后武,张建影,等. 中医药治疗颈动脉粥样硬化斑块临床疗效的Meta分析[J]. 中医药学报,2015,43(3):20-24.
[2] 钟伟,邢庆盛,刘志刚,等. 益气活血方治疗冠心病心绞痛临床研究[J]. 中医学报,2014,29(3):402-403.
[3] 黄玫,曲晶,李晓天,等. 黄芪化学成分及对心血管系统作用的研究进展[J]. 中国老年学杂志,2009,29(11):1451-1453.
[4] 万春平. 黄芪皂苷类组分生物活性研究进展[J]. 云南中医中药杂志,2011,32(8):79-81.
[5] Liu QS,Wang HF,Sun AK,et al. A comparative study on inhibition of total astragalus saponins and astragaloside IV on TNFR1-mediated signaling pathways in arterial endothelial cells[J]. PLoS ONE,2014,9(7):e101504.
[6] 杨婉薇. 黄芪注射液联合西药治疗冠心病心绞痛80例疗效观察[J]. 中国社区医师,2013(20):24-25.
[7] 张其乐. 黄芪注射液联合西药治疗冠心病心绞痛的疗效对比观察[J]. 中国社区医师,2013(43):28-29.
[8] 姚萍,雷艳蓉,唐恩东. 黄芪注射液治疗冠心病心绞痛的临床观察[J]. 四川中医,2004,22(7):52-53.
[9] 赵岚. 黄芪注射液治疗冠心病心绞痛临床研究[J]. 中国中医药信息杂志,2007,14(4):81-82.
[10] 冯国雯,王红勇. 黄芪注射液治疗冠心病心绞痛气虚证的临床观察[J]. 华北煤炭医学院学报,2003,5(1):36.
[11] 李新贵,陈艳玲,郭张强. 黄芪注射液治疗劳累性心绞痛临床评价[J]. 湖北省卫生职工医学院学报,1999(3),24-26.
[12] 徐新毅. 黄芪注射治疗冠心病心绞痛疗效观察[J]. 黑龙江中医药,2001(3):8-9.
[13] 赵嫦颖. 黄芪总皂苷氯化钠注射液治疗冠心病心绞痛(气虚血瘀型)的临床疗效观察[D]. 沈阳:辽宁中医药大学,2010.
[14] 肖遥. 黄芪总皂苷氯化钠注射液治疗冠心病心绞痛(气虚血瘀证)临床观察[D]. 武汉:湖北中医学院,2008.
[15] 王玉珠. 黄芪总皂苷氯化钠注射液治疗冠心病心绞痛的疗效[J]. 中国保健营养,2012,22(22):5437-5438.
[16] 罗洋,邹澍宣,黄宇虹. 黄芪甲苷氯化钠注射液治疗冠心病心绞痛220例安全性及有效性评价[J]. 天津中医药大学学报,2008,27(1):11-14.
[17] 张文艳. 黄芪甲苷葡萄糖注射液治疗冠心病稳定型劳累性心绞痛的III期临床研究[D]. 成都:成都中医药大学,2008.

备注/Memo

备注/Memo:
* 基金项目: 国家自然科学基金面上项目(81573823)
收稿日期: 2016 - 12- 13
作者简介: 王海芳(1972-),女,山西阳泉人,博士,助理研究员,研究方向:中药抗动脉粥样硬化分子机制。
△通信作者:刘勤社,E-mail:lqsspph@126.com
更新日期/Last Update: 2017-02-10