我们的网站为什么显示成这样?

可能因为您的浏览器不支持样式,您可以更新您的浏览器到最新版本,以获取对此功能的支持,访问下面的网站,获取关于浏览器的信息:

|本期目录/Table of Contents|

凝血及炎症指标对下肢丹毒进展的影响分析(PDF)

《云南中医学院学报》[ISSN:1000-2723/CN:53-1048/R]

期数:
2017年01期
页码:
53-55,59
栏目:
临床研究
出版日期:
2017-02-20

文章信息/Info

Title:
Analysis of the Effect of Coagulation and Inflammation Index of Lower Limb Erysipelas Progress
作者:
李文惠1郑英杰2黄海1毛丽萍1何伟1柳国斌1
1. 上海中医药大学附属曙光医院外七科,上海 201203;2. 山东省潍坊寿光市皮肤病防治站,山东 寿光 262700
Author(s):
LI Wenhui1ZHENG Yingjie2HUANG Hai1MAO Liping1HE Wei1LIU Guobin1
1. Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;2. Shandong Weifang Shouguang Skin Disease Prevention and Control Station, Shouguang 262700, China
关键词:
下肢丹毒 凝血功能 炎症指标
Keywords:
limb erysipelas coagulation function inflammation index
分类号:
R269
DOI:
10.19288/j.cnki.issn.1000-2723.2017.01.013
文献标识码:
A
摘要:
目的 探索凝血及炎症相关指标与下肢丹毒发生、发展的关系。方法 收集58例下肢丹毒患者(参照疾病进展过程分为急性期28例及慢性期30例)和28例同期健康体检患者的基本资料,并采集凝血指标和C反应蛋白等炎症指标,采用t检验、卡方检验、二元Logistic回归分析等方法进行统计分析。结果 在基线资料具有可比的前提下,丹毒组D-二聚体、纤维蛋白原及C反应蛋白与健康对照组均有统计学差异(P<0.05);D-二聚体、纤维蛋白原高于正常范围为丹毒发生的危险因子,凝血酶原活动度为丹毒发生的保护因子。相比急性期而言,丹毒慢性期的纤维蛋白原、白细胞及中性粒细胞百分比降低,淋巴细胞百分比及D-二聚体增高(P<0.05)。结论 血清D-二聚体及C反应蛋白等凝血炎症指标在丹毒发生、发展过程中起到重要作用,下肢丹毒治疗中应关注凝血及炎症指标异常。
Abstract:
Objective To explore the relationship between coagulation and inflammation index and erysipelas progress. Methods Collecting 58 cases of erysipelas patients(divided into reference group in acute stage 28 cases and chronic stage 30 cases) and 28 cases of healthy patients’ clinical data, including inflammation index and coagulation function, and analyzed the results. Results On the premise that the baseline data is comparable, there were significant statistical differences between the two groups in CRP, D-dimer, fibrinogen(P<0.05). D-dimer and fibrinogen were higher than the normal range as a risk factor for the occurrence of erysipelas, prothrombin activity as a protective factor erysipelas occurrence. In acute phase and chronic phase group, the white blood cells, neutrophils, fibrinogen decreased, lymphocytes and D-dimer were increased in the chronic phase. Conclusions Serum CRP and D-dimer and other coagulation index plays an important role in erysipelas occurrence and development process. We should pay more attention to the coagulation detection in lower limb erysipelas.

参考文献/References

[1] 王素梅,于彬. 丹毒中医辨证验案举隅[J]. 山西医药杂志,2016,45(18):2190-2191.
[2] 袁震宇. 中西医结合法治疗下肢丹毒28例临床观察[C]//《临床心身疾病杂志》2015年12月研讨会综合刊. 2015:305.
[3] Vanhooteghem O, Szepetiuk G,Paurobally D, et a1. Chronic interdigital dermatophytic infection:a common lesion associated withpotentially severe consequences[J]. Diabetes Res Clin Pract. 2011. 9l(1):23-25.
[4] Picard D,K1ein A,Grigioni S,et a1. Risk factors for abscess formation in patients with superficial cellulitis(erysipelas) of the leg[J]. Br J Dermatol,2013,168(4):859-863.
[5] Pereira de Godoy JM,Galacini Massari P,Yoshino Rosinha M,et a1. Epidemiological data and comorbidities of 428 patients hospitalized with erysipelas[J]. Angiology,2010,61(5):492-494.
[6] Vata D,Solovastru LG,Vata A,et a1. Demographic,clinical and laboratory characteristics of erisypelas in the period 200l-2010[J]. Rev Med Chir Soc Med Nat lasi,2011,115(4):1042-1047.
[7] Mahé A, Destelle JM, Bruet A, et al. Deep venous thromboses in erysipelas of the leg. A prospective study of 40 cases[Article in French][J]. Presse Med,1992,21(22):1022-1024.
[8] 刘晶晶,刘宏杰,闫薇,等. 下肢丹毒合并深静脉血栓1例[J]. 华西医学,2008,23(6):1474-1475.
[9] Perrot JL,Perrot S,Laporte Simitsidis S. Is anticoagulant therapy useful when treating erysipelas?[Article in French][J]. Ann Dermatol Venereol,2001,128(3 Pt 2):352-357.
[10] 王春雨,高永红,张英. 下肢丹毒并发深静脉血栓1例[J]. 中国现代医药杂志,2012,14(12):86-87.
[11] 张学军. 皮肤性病学[M]. 7版. 北京:人民卫生出版社,2008:167.
[12] 国家中医药管理局. 中医病证诊断疗效标准[S]. 南京:南京大学出版社,1994:124-125.
[13] 许永楷. 中医药治疗丹毒研究进展[C]//中华中医药学会周围血管病分会. 中华中医药学会周围血管病分会2010年学术大会论文集. 上海:中华中医药学会周围血管病分会,2010:3.
[14] 杜娟. 中医药治疗下肢丹毒的研究进展概况[J]. 内蒙古中医药,2011(5):96-97.
[15] 朱卉雯,田静,李鑫,等. 中西医结合治疗下肢丹毒[J]. 吉林中医药,2014,34(8):810-812.
[16] 姜立媛,普雄明. 丹毒53 例肾损害与纤溶凝血系异常的检测[J]. 中国皮肤性病学杂志,2014,28(8):803-804.

备注/Memo

备注/Memo:
* 基金项目: 上海市科学技术委员会科研计划项目(16401902200)
收稿日期: 2016 - 11- 26
作者简介: 李文惠(1989-),女,山东青岛人,在读博士研究生,研究方向:中西医结合周围血管病。
△通信作者:柳国斌,E-mai:drliuguobin@163.com
更新日期/Last Update: 2017-02-10