我们的网站为什么显示成这样?

可能因为您的浏览器不支持样式,您可以更新您的浏览器到最新版本,以获取对此功能的支持,访问下面的网站,获取关于浏览器的信息:

|本期目录/Table of Contents|

热毒宁注射液治疗医院获得性肺炎前后的外周血NLR和CRP的相关性(PDF)

《云南中医学院学报》[ISSN:1000-2723/CN:53-1048/R]

期数:
2017年05期
页码:
40-43
栏目:
临床研究
出版日期:
2017-12-16

文章信息/Info

Title:
Correlation of Neutrophil-to-lymphcyte Ratio(NLR) and C-reactive Protein(CRP) in Treating Hospital-acquired Pneumonia(HAP) Patients with Reduning Injection before and after Therapy
作者:
董斌斌1赵普庆2贾维2刘欣燕2李藜3杨沁彤2沈高翔2梁蔚蔚4
1. 复旦大学附属华山医院北院,上海 201907;2. 上海中医药大学附属上海市中西医结合医院,上海 200082;3. 上海市黄浦区中心医院,上海 200002;4. 云南省第一人民医院,云南 昆明 650032
Author(s):
DONG Binbin1 ZHAO Puqing2 JIA Wei2 LIU Xinyan2 LI Li3 YANG Qintong2 SHENG Gaoxiang2 LIANG Weiwei4
1. Huashan Hospital North Affiliated to Fudan University, Shanghai 201907, China;2. Shanghai Traditional Chinese Medicine Integrated Hospital Affiliated to ShanghaiTraditional Chinese Medicine University, Shanghai 200082, China;3. Shanghai Huangpu District Central Hospital, Shanghai 200002, China;4. The First People ’s Hospital of Yunnan Province, Kunming 650032, China
关键词:
医院获得性肺炎热毒宁注射液外周血中性粒细胞/淋巴细胞比值C反应蛋白相关性
Keywords:
hospital-acquired pneumonia(HAP) Reduning injection neutrophil-to-lymphcyte ratio(NLR) C-reactive protein(CRP) correlation
分类号:
R259
DOI:
10.19288/j.cnki.issn.1000-2723.2017.05.009
文献标识码:
A
摘要:
目的 探讨热毒宁注射液治疗医院获得性肺炎前、后的外周血NLR和CRP的相关性。方法 入选的HAP患者共计100例,在治疗前、后行外周血全血细胞计数及分类检测和C反应蛋白(C-reactive protein,CRP)等检查。结果 (1)入选的HAP患者以男性老年人多见,平均年龄(70.74±15.00)岁,男∶女比为71∶29;(2)入选的HAP患者在治疗前、后比较发现外周血WBC、NC、LC、NLR和CRP均有显著差异(均P<0.05);(3)Spearman或Pearson相关性检验的结果为外周血NLR和血清CRP呈正相关(r或rs=0.538,P<0.01)。结论 热毒宁注射液治疗HAP患者有效,它不仅具有降低患者机体肺部的炎症反应,而且外周血NLR和血清CRP的正相关可能是其取效的关键。
Abstract:
Objective To investigate the correlation of NLR and CRP in treating HAP patients with Reduning injection before and after therapy. Methods One hundred HAP patients were enrolled. Peripheral blood of White blood count(WBC) and classification detection and CRP test were performed before and after therapy. Results (1) It was more common in the men aged (average age was 70. 74±15. 00 years old, male-female ratio was 71 to 29). (2) Peripheral blood of WBC, neutrophil count(NC), 1ymphocyte count(LC), neutrophil-to-lymphcyte ratio(NLR) and C-reactive Protein(CRP) in hospital-acquired pneumonia patients were significant difference before and after therapy(all P<0.05). (3) Spearman or Pearson correlation analysis showed that NLR had positive correlation with CRP(r or rs=0.538, P<0.01). Conclusion Reduning injection could treat HAP patients effectively after therapy, which reflected it could lower pulmonary inflammation of the patients, and the positive correlation of NLR and CRP could further illustrate the key to the therapy.

参考文献/References

[1] 王辰,王建安. 内科学[M]. 3版. 北京:人民卫生出版社,2015:61-87.
[2] Seligman R,Ramos-Lima LF,Olivira Vdo A,et al. Risk factors for infection with multidrug-resistant bacteria in non-ventilated patients with hospital–acquired pneumonia[J]. J Bras Pneumol,2013,39(3):339-348.
[3] Li C,Duan J,Liu S,et al. Assessing the risk and disease burden of Clostridium difficile infection among patients with hospital-acquired pneumonia at a University Hospital in Central China[J]. Infection,2017,45(5):621-628.
[4] American Thoracic Society, Infectious Disease Society of America. Guidelines for the management of adults with hospital-acquired,ventilator-associated,and healthcare-associated pneumonia[J]. Am J Respir Crit Care Med,2005,171(4):388-416.
[5] Woodhead M,Blasi F,Ewig S,et al. Guidelines for the management of adults lower respiratory tract infections:summary[J]. Cl in Microbiol infect,2011,17:1.
[6] Günay E,Sarinc Ulasli S,Akar O,et al. Neutrophil-to-lymphocyte ratio in chronic obstructive pulmonary disease:a retrospective study[J]. Inflammation,2014,37(2):374-380.
[7] Biljak VR,Rumora L,Cepelak I,et al. Gamma-glutamyltransferase and C-reactive protein in stable chronic obstructive pulmonary disease[J]. Coll Antropol,2013,37(1):221-227.
[8] 王震,史金英,宋宁. 中性粒细胞/淋巴细胞比值对社区获得性肺炎严重程度的评估价值[J]. 河北医药,2015,37(8):1211-1212.
[9] 贾维,金忠富,成旭明. 热毒宁注射液联合莫西沙星治疗社区获得性肺炎45例[J]. 福建中医药,2011,42(2):42-43.
[10] 周新,万欢英,朱惠莉,等. 哌拉西林/他唑巴坦治疗医院获得性肺炎的多中心临床研究[J]. 中国呼吸与危重监护杂志,2009,8(1):20-23.
[11] 曹江红,李光辉. 美国感染病学会和美国胸科学会2016年成人医院获得性肺炎和呼吸机相关性肺炎的处理临床实践指南[J]. 中国感染与化疗杂志,2017,17(2):209-213.
[12] 王辰. 呼吸与危重症医学[M]. 北京:人民卫生出版社,2011:106-113.
[13] 徐秀,朱桂花,唐杰,等. 热毒宁的药理作用与临床应用[J]. 社区医学杂志,2011,19(1):23-24.
[14] 颜正华. 中药学[M]. 2版. 北京:人民卫生出版社,2010:148-150.
[15] 李宁,程齐俭,韩立中,等. 上海地区成人医院获得性肺炎易患因素、病原学及预后分析[J]. 中国感染与化疗杂志,2011,11(5):339-343.
[16] 罗仁,牟文玉. 医院获得性肺炎患者的病原学及流行病学特征分析[J]. 医学前沿,2017,7(24):22-23.
[17] 唐鸿. 热毒宁注射液联合头孢西丁钠治疗社区获得性肺炎临床观察[J]. 山西中医,2015,31(8):17-18.
[18] 栾禹博,侯嘉娜. 哌拉西林舒巴坦钠、左氧氟沙星联合热毒宁治疗社区获得性肺炎疗效观察[J]. 现代中西医结合杂志,2015,24(13):1448-1450.
[19] 陈勇,蒋宇桐,杨慧敏. 热毒宁治疗儿童社区获得性肺炎的随机对照双盲试验研究[J]. 云南中医学院学报,2015,38(4):73-77.
[20] 周蔚华,黄汝成,赵贝贝. 祛痰生新针法治疗卒中相关性肺炎的临床疗效观察[J]. 云南中医学院学报,2015,38(2):53-54.

备注/Memo

备注/Memo:
* 基金项目: 上海市卫生和计划生育委员会科研课题面上项目(201640098);上海中医药大学附属上海市中西医结合医院 院级科研项目(2016年);虹口区卫生和计划生育委员会医学科研课题(虹卫1604-02)
收稿日期: 2017 - 10- 18
作者简介: 董斌斌(1980-),男,河南安阳人,硕士,主治医师,研究方向:呼吸系统疾病的中西结合诊治。
△通信作者: 贾维,E-mail:jia11wei11@sina.com
更新日期/Last Update: 2017-10-20