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中药足浴熏洗联合滋膵蠲痹方治疗糖尿病周围神经病变的临床研究(PDF)

《云南中医学院学报》[ISSN:1000-2723/CN:53-1048/R]

期数:
2017年05期
页码:
49-53
栏目:
临床研究
出版日期:
2017-12-16

文章信息/Info

Title:
Clinical Research on Combined Chinese Medicine Foot Bath and Zicui Juanbi Decoctionin Treating Diabetic Peripheral Neuropathy
作者:
张艺1严军1陆聆韵2徐国海1胡春平1冯珍凤1
1. 上海市嘉定区中医医院,上海 201899;2. 上海交通大学医学院附属瑞金医院北院,上海 201800
Author(s):
ZHANG Yi1 YAN Jun1 LU Lingyun2 XU Guohai1 HU Chunping1 FEN Zhengfeng1
1. Shanghai Jiading Hospital of Traditional Chinese Medicine, Shanghai 201899, China;2. Ruijin Hospital North Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 201800, China
关键词:
中药足浴滋膵蠲痹方2型糖尿病周围神经病变
Keywords:
Chinese medicine foot bath Zicui Juanbi decoction type 2 diabetes peripheral neuropathy
分类号:
R259
DOI:
10.19288/j.cnki.issn.1000-2723.2017.05.011
文献标识码:
A
摘要:
目的 观察中药足浴熏洗联合滋膵蠲痹方治疗糖尿病周围神经病变患者的临床疗效。方法 将132例糖尿病周围神经病变患者随机分为温水足浴组(对照组)、温水足浴+滋膵蠲痹方组(治疗1组)、中药足浴组(治疗2组)及中药足浴+滋膵蠲痹方组(治疗3组),每组33例,给予相应治疗,疗程8周,观察治疗前后临床症状疗效、多伦多临床评分系统(TCSS)、血糖、足背动脉流速及神经传导速度的变化。结果 ①对照组、治疗1组、治疗2组及治疗3组的临床症状有效率分别为45.5%、80.6%、75.0%、90.0%,治疗1组和治疗3组的总有效率高于对照组(P<0.01)。②治疗后,4组TCSS评分较治疗前均显著降低(P<0.01),治疗3组TCSS评分明显低于对照组(P<0.01),低于治疗1组和治疗2组(P<0.05)。③治疗后,治疗1组、治疗3组血糖(FPG、2hPG)水平显著下降(P<0.05,P<0.01),且2组FPG、2hPG水平低于对照组(P<0.05)。④治疗后,除对照组外的3组治疗后足背动脉流速较治疗前明显升高(P<0.01),治疗1组、治疗2组足背动脉流速水平高于对照组(P<0.05),治疗3组足背动脉流速水平明显对照组(P<0.01)。⑤治疗后,4组神经传导速度较治疗前均有所改善(P<0.05,P<0.01);治疗3组的胫神经MCV和腓浅神经SCV明显高于对照组(P<0.01),胫神经MCV高于治疗1组及治疗2组(P<0.05)。结论 中药足浴熏洗联合滋膵蠲痹方能有效改善糖尿病周围神经病变患者临床症状、外周血流动力学及下肢神经传导速度。
Abstract:
Objective To observe the clinical effect of combined chinese medicine foot bath and Zicui Juanbi Decoction in the treatment of diabetic peripheral neuropathy(DPN). Methods One hundred and thirty two cases with DPN were randomized into four groups(Control group, Treatment group 1, Treatment group 2 and Treatment group 3, 33 cases in each groups), and treated by respective medthods for eight weeks. The clinical efficacy, Toronto clinical scoring system(TCSS), blood glucose, velocity of dorsal pedal artery and Nerve conduction velocity were observed before and after treatment. Results ① The clinical effective rate was 45.5%, 80.6%, 75. 0% and 90.0% respectively in control group, treatment group 1, treatment group 2 and treatment group 3, with higher rate in treatment group 1 and 3 than in the control group. ② After treatment, the TCSS were significantly lowered in four groups(P<0.01), the TCSS was lower in the Treatment group 3 than in the control group(P<0.01), and lower than in treatment group 1 and group 2(P<0.05). ③ After treatment, the levels of blood glucose(FPG, 2hPG) were reduced in treatment group 1 and treatment group 3(P<0.05, P<0.01), with lower level in the in treatment group 1 and group 3 than in the control group(P<0.05). ④ After treatment, The velocity of dorsal pedal artery in the latter group was increased(P<0.01), with higher velocity in treatment group 1 and group 2 than in the control group(P<0.05), and with significant higher velocity in treatment group 3 than in the control group(P<0.01). ⑤ After treatment, The MCV of the tibial nerve and SCV of the superficial peroneal nerve were increased in four groups(P<0.05, P<0.01), with significant higher velocity in treatment group 3 than in the control group(P<0.01), and the MCV of the tibial nerve in treatment group 3 was higher than treatment group 1 and 2. Conclusion Combined chinese medicine foot bath and Zicui Juanbi Decoction is quite effective against diabetic peripheral neuropathy in relieving clinical symptoms, peripheral hemodynamics and nerve conduction velocity.

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备注/Memo

备注/Memo:
* 基金项目: 上海市嘉定区科委医学科研课题项目(2014—KW—07);上海市嘉定区中医重点专科项目(2017-ZYZDZK-03)
收稿日期: 2017 - 10- 17
作者简介: 张艺(1984-),女,上海嘉定人,硕士,主治医师,主要从事中医内分泌工作。
△通信作者: 徐国海,E-mail:xuguohai2000@163.com
更新日期/Last Update: 2017-10-20