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仙灵骨葆与玻璃酸钠单用与合用治疗膝骨关节炎的疗效比较*(PDF)

《云南中医学院学报》[ISSN:1000-2723/CN:53-1048/R]

期数:
2017年06期
页码:
72-74
栏目:
临床研究
出版日期:
2018-03-19

文章信息/Info

Title:
The Comprehensive Study of Clinical Effect and Safety for the Patients with Knee Osteoarthritis Treated by Sodium Hyaluronate and Xianlinggubao Alone and in Combination
作者:
钱玉凤李军陈国友王敏
宣城市人民医院药学部,安徽 宣城 242000
Author(s):
QIAN Yufeng LI Jun CHEN Guoyou WANG Min
Department of Pharmacy, Xuancheng People’s Hospital, Xuancheng 242000, China
关键词:
仙灵骨葆 玻璃酸钠 膝骨关节炎 中医药 疗效观察
Keywords:
Xianlinggubao sodium hyaluronate knee osteoarthritis traditional Chinese medicine curative effect observation
分类号:
R274
DOI:
10.19288/j.cnki.issn.1000-2723.2017.06.021
文献标识码:
A
摘要:
目的 观察独用与合用仙灵骨葆和玻璃酸钠治疗膝骨关节炎的临床效果比较。方法 自2015年10月至2016年10月在我院治疗的膝骨关节炎患者90例,按照随机分配原则平均分为A、B、C 3组30例。其中,A组单独采用仙灵骨葆进行治疗;B组单独采用玻璃酸钠进行治疗;C组仙灵骨葆与玻璃酸钠合用进行治疗。观察各组WOMAC(Western Ontario and McMaster Universities)量表得分与治疗不良反应状况。结果 C组患者的WOMAC得分为17,31±6.90,明显低于A组与B组的30.43±7.07和28.25±7.19,且3组比较,P<0.05,差异具有统计学意义,无不良反应。结论 单用仙灵骨葆或玻璃酸钠均可治疗膝骨关节炎,如将两者合用,可以取得更好疗效,值得临床推广。
Abstract:
Objective To research the effect and safety of sodium hyaluronate and xianlinggubao alone and in combination for the patients with knee osteoarthritis. Methods During the time of October 2014 to October 2016, 90 patients with knee osteoarthritis were selected and divided into A, B and C groups with the principle of voluntary and randomly assignment. The 30 patients ingroup A were treated by xianlinggubao only and the 30 patients ingroup B were treated by sodium hyaluronate only, while the 30 patients in group C were treated by sodium hyaluronate and xianlinggubao. To observe the WOMAC scores and adverse events of the 3 groups. Results The WOMAC score in group C was 17.31±6.90, significantly lower than the that of group A and group B, which were 30.43±7.07 and 28.25±7.19, and the results above were statistically significance while P<0.05. From the view of adverse reactions, there were no patients appeared adverse reaction in group C. Conclusion Sodium hyaluronate and xianlinggubao alone and in combination all can treated knee osteoarthritis, but compared with using xianlinggubao and sodium hyaluronate alone. It can effectively improve the clinical efficacy to use them in combination which can also cut down the adverse reactions and deserved to be used in clinical.

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备注/Memo

备注/Memo:
* 基金项目: 宣城市科技计划项目(YFZD2010112)
收稿日期: 2017 - 10- 28
作者简介: 钱玉凤(1980-),女,安徽宣城人,主管药师,研究方向:医院药学及药物临床应用研究。
更新日期/Last Update: 2017-12-20