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益气通脉汤对冠心病不稳定性心绞痛患者血管内皮功能的影响*(PDF)

《云南中医学院学报》[ISSN:1000-2723/CN:53-1048/R]

期数:
2018年01期
页码:
61-64
栏目:
临床研究
出版日期:
2018-06-30

文章信息/Info

Title:
Effect of Yiqi Tongmai Decoction on Vascular Endothelial Function in Patients with Unstable Angina Pectoris
作者:
姜延娟李景春易璐莹王金萍
北京市昌平区中西医结合医院,北京 102208
Author(s):
JIANG Yanjuan LI Jingchun YI Luying WANG Jinping
(Beijing Changping Hospital of Integrated Chinese and Western Medicine, Beijing 102208, China)
关键词:
益气通脉汤 冠心病不稳定心绞痛 血管内皮功能
Keywords:
Yiqi Tongmai Decoction unstable angina pectoris of coronary heart disease vascular endothelial function
分类号:
R259
DOI:
10.19288/j.cnki.issn.1000-2723.2018.01.015
文献标识码:
A
摘要:
目的探讨分析益气通脉汤对冠心病不稳定性心绞痛患者血管内皮功能的影响。方法选择冠心病不稳定性心绞痛患者125例,将其随机分为观察组65例、对照组60例,对照组给予常规西药治疗,观察组在对照组基础上给予益气通脉汤治疗,比较2组治疗前后心功能、心肌再灌注损伤以及血管内皮功能指标变化。结果治疗后2组心绞痛发作频率以及心绞痛持续时间均明显降低(P<0.05),且观察组降低程度明显高于对照组(P<0.05)。治疗后2组心功能指标均明显改善(P<0.05),且观察组改善情况明显优于对照组(P<0.05)。2组治疗后NO水平较治疗前显著升高、而ET-1水平较治疗前显著降低(P<0.05),且观察组变化程度优于对照组(P<0.05)。结论益气通脉汤联合常规治疗可有效缓解冠心病不稳定性心绞痛患者的临床症状,改善患者心功能以及血管内皮功能,值得临床推广运用。
Abstract:
Objective To oberserve effect of Yiqi Tongmai Decoction for vascular endothelial function in patients of unstable angina pectoris of coronary heart disease. Methods 125 patients with unstable angina pectoris treated in our hospital were randomly divided into 65 cases in the observation group and 60 in the control group. The patients in the control group were treated with conventional western medicine, and the observation group was treated with Yiqi Tongmai Decoction on the basis of the control group. The changes of cardiac function, myocardial reperfusion injury and vascular endothelial function index before and after treatment were compared between the two groups. Results After treatment, the frequency of angina pectoris and the duration of angina were significantly decreased in the 2 groups(P<0.05), and the degree of reduction in the observation group was significantly higher than that of the control group(P<0.05). After treatment, the indexes of cardiac function of the 2 groups were obviously improved(P<0.05), and the improvement of the observation group was obviously better than the control group(P<0.05). After treatment, the level of NO in the 2 groups was significantly higher than before treatment, and the level of ET-1 was significantly lower than before treatment(P<0.05), and the degree of change of the observation group was significantly better than the control group(P<0.05). Conclusion Yiqi Tongmai Decoction combined with routine treatment can effectively improve the clinical symptoms of unstable angina pectoris patients, and effectively improve cardiac function and endothelial function of patients, which is worthy of clinical application.

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备注/Memo

备注/Memo:
基金项目: 首都卫生发展科研专项项目(2011-1017-05) 收稿日期: 2018 - 01- 03 作者简介: 姜延娟(1980-),女,硕士,主治医师,从事心内科工作。 通信作者: 王金萍,E-mail:13146461234@163. com
更新日期/Last Update: 2018-06-30