我们的网站为什么显示成这样?

可能因为您的浏览器不支持样式,您可以更新您的浏览器到最新版本,以获取对此功能的支持,访问下面的网站,获取关于浏览器的信息:

|本期目录/Table of Contents|

加味参苓白术散对溃疡性结肠炎患者血清SOD、MDA水平的影响*(PDF)

《云南中医学院学报》[ISSN:1000-2723/CN:53-1048/R]

期数:
2018年03期
页码:
65-68
栏目:
临床研究
出版日期:
2018-12-15

文章信息/Info

Title:
Effect of Shenling Baizhu Powder on Ulcerative Colitis Patients Serum SOD and MDA
作者:
史伟孙东雪胡阳
(辽宁中医药大学附属第三医院,辽宁 沈阳 110000)
Author(s):
SHI Wei SUN Dongxue HU Yang
(The Third Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shengyang 110000, China)
关键词:
参苓白术散 溃疡性结肠炎 SOD MDA
Keywords:
Shenling Baizhu powder ulcerative colitis SOD MDA
分类号:
R259
DOI:
10.19288/j.cnki.issn.1000-2723.2018.03.015
文献标识码:
A
摘要:
目的观察加味参苓白术散对溃疡性结肠炎患者血清SOD、MDA水平的影响。方法选择94例溃疡性结肠炎患者,将其随 机分为观察组49例、对照组45例,对照组给予美沙拉秦治疗,观察组联合给予加味参苓白术散,2组均治疗6个月,随访6个 月。比较2组患者临床疗效、血清SOD和MDA变化情况、血清CRP变化情况、随访复发率。结果观察组临床疗效优于对照组 (P<0.05)。治疗后患者血清SOD明显升高、MDA明显降低(P<0.05),且观察组SOD高于对照组、MDA低于对照组(P<0.05 )。治疗后2组血清CRP显著降低(P<0.05),且观察组低于对照组(P<0.05)。观察组随访复发率显著低于对照组 (P<0.05)。结论加味参苓白术散联合美沙拉秦缓释颗粒剂治疗溃疡性结肠炎具有着显著的临床疗效,同时可有效降低患 者治疗后复发率,其作用机制可能与清除机体氧自由基以及减轻机体炎症反应有关,值得临床推广。
Abstract:
Objective Analysis on the effect of Shenling Baizhu powder on ulcerative colitis patients serum SOD and MDA levels. Methods 94 cases of ulcerative colitis patients in our hospital, were randomly divided into the observation group of 49 cases, 45 cases in the control group, the control group was given the salad Qin granule treatment, the observation group in the control group were given with modified shenglingbaizhusan, two groups were treated for 6 months, followed up for 6 months. The clinical efficacy of the two groups, the changes of serum SOD and MDA, the change of serum CRP, and the recurrence rate of follow-up were compared. Results The clinical effect of the observation group was significantly better than that of the control group(P<0.05). After treatment, serum SOD increased significantly and MDA decreased significantly in two groups(P<0.05). After treatment, SOD in observation group was higher than that in control group and MDA was lower than that in control group(P<0.05). After treatment, the serum CRP decreased significantly in the two groups(P<0.05), and the observation group was lower than that of the control group(P<0.05). The recurrence rate of the patients in the observation group was significantly lower than that of the control group(P<0.05). Conclusion Modified SHENLINGBAISHU Mesalazine SR Granules combined treatment of ulcerative colitis has significant clinical efficacy, and can effectively reduce the recurrence rate of the patients after treatment, the mechanism may be related to scavenging oxygen free radicals and reduce the inflammatory reaction, which is worthy of clinical promotion.

参考文献/References


[1] 朱庆平,沈洪,朱磊. 中医对溃疡性结肠炎患者瘀血病机的认识[J]. 浙江中医药大学学报,2013,37(4):480- 482.
[2] 刘春雨,卢彩宝,叶秋,等. 健脾补肾方联合柳氮磺吡啶对慢性溃疡性结肠炎患者疗效及炎症因子影响[J]. 云南中医 学院学报,2018,41(1):65-67.
[3] SYLVIE PILLET, BRUNO POZZETTO, XAVIER ROBLIN. Cytomegalovirus and ulcerative colitis:Place of antiviral therapy[J]. World J Gastroenterol,2016,22(6):2030-2045.
[4] 祁向争,刘洁. 溃疡性结肠炎动物模型研究进展[J]. 天津中医药大学学报,2010,29(4):220-222.
[5] BOPANNA S, ANANTHAKRISHNAN A N, KEDIA S, et al. Risk of colorectal cancer in Asian patients with ulcerative colitis:a systematic review and meta-analysis[J]. Lancet Gastroenterol Hepatol,2017,2(4): 269-276.
[6] 姚惠芬,陈务华,周毅. 溃疡性结肠炎动物模型研究概况[J]. 天津药学,2006,18(4):72-74.
[7] 李雅琳. 姜黄素对溃疡性结肠炎大鼠中Toll样受体4/NF-κB通路的影响[D]. 蚌埠:蚌埠医学院,2012.
[8] 李景南,郑威扬,钱家鸣,等. 溃疡性结肠炎相关结直肠癌临床特点及癌变相关蛋白的表达[J]. 中华消化杂志,2010 ,30(11):808-810.
[9] 黄循铷,王承党,王瑞幸,等. 溃疡性结肠炎小鼠肠道通透性改变与TNF-α及NF-κB P65的关系[J]. 中国应用生理学 杂志,2016,32(2):112-115.
[10] HIRAYAMA Y, ANDO T, HIROOKA Y, et al. Characteristic endoscopic findings and risk factors for cytomegalovirus-associated colitis in patients with active ulcerative colitis[J]. World J Gastrointest Endosc,2016,8(6):301-309.
[11] 王叙国,王淑琴,向萍,等. 溃疡性结肠炎的中西医治疗近况[J]. 东南国防医药,2014,16(1):76-77.
[12] 刘文奇,杨晓航,李舒,等. 溃疡性结肠炎中医证候与免疫及肠道菌群紊乱关系研究进展[J]. 吉林中医药,2017, 37(6):639-642.
[13] 张和平. 三联疗法治疗溃疡性结肠炎38例[J]. 中国肛肠病杂志,2005,25(7):53.
[14] 卓毓春. “白头翁汤”直肠给药对慢性溃疡性结肠炎的临床疗效观察[J]. 中药药理与临床,1990(1):44-45.
[15] 张冰,庞雪莹. 谢晶日教授分期论治溃疡性结肠炎经验探析[J]. 中国中医急症,2017,26(12):2133-2135.
[16] G?覵■BSKA D, GUZEK D, ZAKRZEWSKA P, et al. Lycopene,Lutein and Zeaxanthin May Reduce Faecal Blood ,Mucus and Pus but not Abdominal Pain in Individuals with Ulcerative Colitis[J]. Nutrients,2016,8(10) :613.
[17] 林明武,柯晓. 中药灌肠治疗溃疡性结肠炎的研究进展[J]. 北京中医药,2008,27(2):144-146.
[18] 魏国丽,郑学宝,周宇,等. 参苓白术散联合美沙拉嗪治疗脾胃气虚型溃疡性结肠炎疗效及其对血清IL-17、TNF-α 及IL-23水平的影响[J]. 广东医学,2013,34(1):143-145.
[19] 杨家群,熊伟,杨琳,等. 肠炎康颗粒对溃疡性结肠炎患者血清TNF-α,25-(OH)D,YKL-40水平的影响[J]. 现代 生物医学进展,2017,17(18):3494-3497.
[20] 邹莉波,刘悦,吴琦,等. 青黛散抗溃疡性结肠炎的作用研究[J]. 中国医科大学学报,2006,35(1):15-16.

备注/Memo

备注/Memo:
收稿日期: 2018 - 06- 13 *
基金项目: 第六批全国老中医药专家学术经验继承人项目(国中医药人教发[2017]29号)
第一作者简介: 史伟(1983-),男,主管药师,研究方向:中药药理与药效。
更新日期/Last Update: 2018-12-30