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芩珠凉血合剂对湿疹患者外周血GRα受体的影响(PDF)

《云南中医学院学报》[ISSN:1000-2723/CN:53-1048/R]

期数:
2016年01期
页码:
17-20
栏目:
实验研究
出版日期:
2016-02-02

文章信息/Info

Title:
Effect of Qinzhu Liangxue Mixture on Eczema in Peripheral Blood of Patients with GR Receptor Alpha
文章编号:
1000 - 2723(2016)01 - 0017 - 04
作者:
李 苏陈 洁李 斌李福伦缪 晓
上海中医药大学附属岳阳中西医结合医院,上海 200437
Author(s):
LI Su CHEN Jie LI Bin LI Fulun MIAO Xiao
Yueyang Hospital Affiliated to Shanghai University of TCM, Shanghai 200437, China
关键词:
芩珠凉血合剂 皿治林 外周血GRα受体
Keywords:
Qinzhu Liangxue decoction Mizolastine sustained-release tablets peripheral blood GR alpha content
分类号:
R285.6
DOI:
10.19288/j.cnki.issn.1000-2723.2016.01.005
文献标识码:
A
摘要:
目的 观察芩珠凉血合剂对湿疹患者外周血GRα受体的影响。方法 60例湿疹患者随机分为2组。治疗组32例,予芩珠凉血合剂;对照组28例,予咪唑斯汀缓释片(皿治林),均口服治疗4周。检测患者治疗前后外周血GRα受体的含量,并与20例健康的正常人作对照,正常组20例均来自岳阳医院体检中心体检人群。结果 2组湿疹患者外周血GRα受体与正常组作比较,差异有统计学意义(P<0.05);芩珠凉血合剂组治疗前后外周血GRα受体含量比较有显著差异(P<0.05);皿治林组治疗前后外周血GRα受体含量比较无显著差异(P>0.05)。结论 芩珠凉血合剂可以上调湿疹患者外周血GRα含量,皿治林对湿疹患者外周血GRα含量无明显改变。
Abstract:
Objective To observe the effect of Qinzhu Liangxue mixture on eczema in peripheral blood of patients with GR receptor alpha. Methods A total of 60 cases of eczema were randomly divided into group A(32 cases) and group B(28 cases). The patients in group A were treated with Qinzhu Liangxue decoction continuously for 4 weeks. Subjects in group B were treated with Mizolastine Sustained-release Tablets, twice a day continuously for 4 weeks. The content of GR receptor in the peripheral blood of the patients before and after treatment was detected, and compared with 20 healthy controls, which from the physical examination center of the Yueyang Hospital physical center. Results Two groups of eczema patients with peripheral blood GR receptor alpha, differences have significance(P<0.05), compared with normal group, either Qinzhu Liangxue decoction in the treatment group(P <0.05), however there is no significant difference between mizolastine group before and after treatment of peripheral blood GR alpha receptor content(P>0.05). Conclusion Qinzhu Liangxue decoction can upregulation of eczema patients peripheral blood GR alpha content, the content of mizolastine in peripheral blood of patients with eczema and GR alpha no obvious change.

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备注/Memo

备注/Memo:
基金项目: 上海市卫生局课题(20134203);上海市高级中西医结合人才培养项目(ZYSNXD012-RC-ZXY010)
作者简介: 李苏(1987-),女,山东济南人,住院医师,研究方向:中西医结合治疗皮肤病。
通信作者:缪晓,E-mail:lieast@263.net
更新日期/Last Update: 2016-02-28