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蠲痹历节清方治疗急性痛风性关节炎的临床研究(PDF)

《云南中医学院学报》[ISSN:1000-2723/CN:53-1048/R]

期数:
2016年01期
页码:
81-84
栏目:
临床研究
出版日期:
2016-02-02

文章信息/Info

Title:
Clinical Study of Juanbilijieqing Fang in the Treatment of Acute Gouty Arthritis
文章编号:
1000 - 2723(2016)01 - 0081 - 04
作者:
郭玉星1熊 辉2陆小龙2朱方晓1周 彪1周友良1
1. 湖南中医药大学,湖南 长沙 410007;
2. 湖南中医药大学第二附属医院,湖南 长沙 410005
Author(s):
GUO Yuxing1 XIONG Hui2 LU Xiaolong2 ZHU Fangxiao1 ZHOU Biao1 ZHOU Youliang1
l. Hunan University of Chinese Medicine. Changsha 410208, China;
2. The Second Affiliated Hospital, Hunan University of Chinese Medicine, Changsha 410005, China
关键词:
蠲痹历节清方 急性痛风性关节炎 肿瘤坏死因子-α(TNF-α) 白细胞介素-1β(IL-1β) 白细胞介素-6(IL-6)
Keywords:
Juanbilijieqing Fang acute gouty arthritis tumor necrosis factor-α(TNF-α) serum interleukin-1β(IL-1β) serum interleukin-6(IL-6)
分类号:
R259
DOI:
10.19288/j.cnki.issn.1000-2723.2016.01.019
文献标识码:
A
摘要:
目的 通过临床与依托考昔比较,观察蠲痹历节清方治疗急性痛风性关节炎的临床疗效及其对主要炎症因子的影响。方法 将明确诊断的患者随机分为治疗组和对照组,治疗组给予蠲痹历节清方治疗,对照组采用依托考昔片干预。观察治疗前后红肿疼痛等症状体征、C-反应蛋白(CRP)、红细胞沉降率(ESR)及肿瘤坏死因子-α(TNF-α)、血清白细胞介素-1β(IL-1β)、血清白细胞介素-6(IL-6)变化和不良反应。结果 1周疗程后,治疗组与对照组红肿疼痛等症状体征明显改善,两者比较对照组改善症状方面更明显,差异有统计学差异(P<0.05),但红肿总积分两者接近;治疗后CRP、ESR较前明显改善(P<0.05),2组治疗后比较,差异无统计学意义(P>0.05);2组治疗前后血清TNF-α、IL-1β、IL-6均下降,治疗组较对照组更明显,差异亦有统计学意义(P<0.05)。2组不良反应率差异有显著性(P<0.05)。结论 蠲痹历节清方可以有效缓解急性痛风性关节炎患者症状体征,改善其CRP、ESR,抑制血清TNF-α、IL-1β、IL-6的表达,是治疗急性痛风性关节炎的有效方药,值得临床借鉴及进一步研究。
Abstract:
Objective By comparison with the Etoricoxib, observation Juanbilijieqing Fang in treatment of acute gouty arthritis clinical efficacy and effect on the main inflammatory factor. Methods The patients were randomly divided into two groups, the treatment group received Juanbilijieqing Fang treatment, control group with etoricoxib tablets intervention. we observe their changes include of swelling and pain, C-reactive protein(CRP), erythrocyte sedimentation rate(ESR) and tumor necrosis factor-α(TNF-α), serum interleukin-1β(IL-1β), serum interleukin-6(IL-6), and adverse effects. Results After one week of treatment, the symptoms and signs of the treatment group and the control group were significantly improved, and the control group was more obvious, the difference was statistically significant(P<0.05), but the swelling’s total score were close to the two groups. After treatment, CRP and ESR were significantly improved(P<0.05), and there was no significant difference between the two groups(P>0.05). The serum levels of TNF-α, IL-1 and IL-6 were decreased in the two groups after treatment, and the treatment group was more obvious than the control group(P<0.05). There was significant difference in the adverse reaction rate of the two groups(P<0.05). Conclusion Juanbilijieqing Fang can effectively relieve acute gouty arthritis signs and symptoms, improve their CRP, ESR, inhibit the serum TNF-α, IL-1β, IL-6 expression. It is the treatment of acute gouty arthritis effective herbs and deserves widespread use and further study.

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备注/Memo

备注/Memo:
基金项目: 国家自然科学基金(81574005);湖南省自然科学基金(S2013J5043)
作者简介: 郭玉星(1987-),男,湖南湘潭人,在读博士研究生,主要研究方向:中医筋伤及骨病的防治。
通信作者:熊辉,E-mail:xh-hn@sina.com
更新日期/Last Update: 2016-02-28