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岩白菜素偶氮衍生物的制备(PDF)

《云南中医学院学报》[ISSN:1000-2723/CN:53-1048/R]

期数:
2016年02期
页码:
25-29
栏目:
方药研究
出版日期:
2016-04-10

文章信息/Info

Title:
Synthesis of Bergenin Azo Derivatives
作者:
段文越1郭巍怡1邹澄1赵庆2杨为民1陈晨1
1. 昆明医科大学药学院暨云南省天然药物药理重点实验室,云南 昆明 650500;2. 云南中医学院中药学院,云南 昆明 650500
Author(s):
DUAN Wenyue1 GUO Weiyi1 ZOU Cheng1 ZHAO Qing2 YANG Weimin1 CHEN Chen1
1. School of Pharmaceutical Sciences & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500 China;2. School of Chinese Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500 China
关键词:
岩白菜素 含氮衍生物 重氮化偶合反应
Keywords:
ergenin Nitrogenous derivatives Diazo coupling reactioni
分类号:
R284.3
DOI:
10.19288/j.cnki.issn.1000-2723.2016.02.007
文献标识码:
A
摘要:
目的设计合成岩白菜素偶氮衍生物。方法对岩白菜素7位进行结构改造,通过重氮化偶合反应制备其衍生物,并通过波谱法进行结构鉴定。结果制备了7个岩白菜素偶氮衍生物,其中7个化合物均为新化合物。结论这些化合物的合成为大量合成同类衍生物并进行药理活性筛选奠定了研究基础,为岩白菜素的深入研究与开发利用提供新的方法。
Abstract:
Objective To design and synthesize bergenin azo derivatives. Methods A series of bergenin azo derivatives were synthesized by diazo coupling reaction. After purification the compounds were characterized by NMR. Results Seven derivatives were obtained and all of them were new compounds. Conclusions These compounds establish the research foundation for similar derivatives and pharmacological study. This provides a new approach for development and further research of bergenin.

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备注/Memo

备注/Memo:
* 基金项目: 国家自然科学基金(81160388);云南省教育厅科学研究基金项目(2014J042) 收稿日期: 2015 - 11 - 25 作者简介: 段文越(1989-),男,云南昆明人,在读硕士研究生,研究方向:天然药物化学。△通信作者:邹澄,E-mail:zouchengkm@126.com
更新日期/Last Update: 2016-03-20