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虚寒证原发性痛经患者血清氧化应激的变化及金匮温经汤的干预机制(PDF)

《云南中医学院学报》[ISSN:1000-2723/CN:53-1048/R]

期数:
2016年02期
页码:
53-56
栏目:
临床研究
出版日期:
2016-04-10

文章信息/Info

Title:
Change of Oxidative Stress in Asthenia-cold Syndrome of Primary Dysmenorrhea in Serumand the Interventional Mechanis of Jingui Wenjing Decoction
作者:
徐丁洁1张碧溦1徐洪2董玉山1杜晨光1成秀梅3杜惠兰3
1. 华北理工大学中医学院,河北 唐山 063000;2. 华北理工大学医学实验研究中心,河北 唐山 063000;3. 河北中医学院中西医结合学院,河北 石家庄 051000
Author(s):
XU Dingjie1 ZHANG Biwei1 XU Hong2 DONG Yushang1 DU Chenguang1 CHENG Xiumei3 DU Huilan3
1. College of Traditional Chinese Medicine, North China University of Science and Technology, Tangshan 063000, China;2. Research Center of Medical Experiment, North China University of Science and Technology, Tangshan 063000, China;3. College of Integrated Traditional and Western Medicine, Hebei University of Chinese Medical, Shijiazhuang 050091, China
关键词:
虚寒证 原发性痛经 金匮温经汤 氧化应激
Keywords:
asthenia-cold syndrome primary dysmenorrhea Jingui Wenjing decoction oxidative damage
分类号:
R271.11+ 3
DOI:
10.19288/j.cnki.issn.1000-2723.2016.02.015
文献标识码:
A
摘要:
目的探讨虚寒证原发性痛经患者血清氧化应激指标的变化,完善金匮温经汤治疗本病的作用机制。方法收集60例虚寒证原发性痛经患者,给予金匮温经汤连续治疗3个月经周期;60例正常女性作为对照组,比较治疗前后痛经患者血清生殖激素(FSH、LH、E2、P、T)及氧化应激指标(SOD、MDA、GSH-PX、T-AOC)的变化。结果痛经组患者治疗前,血清E2、SOD活性、GSH-PX和T-AOC均显著降低,MDA升高,与正常组比较,差异具有统计学意义(P<0.05或P<0.01);治疗后,血清E2、SOD活性、GSH-PX和T-AOC均有不同程度升高,MDA降低,与治疗前比较,差异具有统计学意义(P<0.05或P<0.01),且治疗后E2、SOD活性、MDA与正常组比较,差异无统计学意义(P>0.05)。结论虚寒证原发性痛经患者存在氧化应激损伤;金匮温经汤能够通过激活机体抗氧化能力缓解机体氧化损伤状态,有效治疗虚寒证原发性痛经。
Abstract:
Objective To discuss the change of oxidative stress in Asthenia-cold syndrome of primary dysmenorrhea in serum, and complete the interventional mechanis of Jin Gui Wenjing decoction to curing the disease. Methods Collected 60 cases with Asthenia-cold Syndrome of Primary Dysmenorrhea, curing with Jingui Wenjing decoction. Collected 60 cases of normal women as control group. Compared the changes of serum reproductive hormones(FSH、LH、E2、P、T) and oxidative stress index(SOD、MDA、GSH-PX、T-AOC) between before and after treatment. Results Dysmenorrhea patients before treatment, the serum E2, SOD, GSH-Px and T-AOC were significantly lower, and MDA increased, compared with normal group, the difference statistically significant(P<0.05 or P<0.01). After treatment, serum E2, SOD, GSH-Px and T-AOC also increased to different extent, MDA decreased, compared with before treatment, statistically significant difference(P<0.05 or P<0.01); And E2, SOD activity and MDA after treatment compared with normal group, there was no statistically significant difference(P>0.05). Conclusion Asthenia-cold Syndrome of Primary Dysmenorrhea have oxidative stress injury; Jingui Wenjing decoction can effectively treat the asthenia-cold syndrome of primary dysmenorr-heal by activating the body’s antioxidant ability to alleviate the body state of oxidative damage.

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备注/Memo

备注/Memo:
* 基金项目: 国家自然科学基金(81503451);河北省自然科学基金(H2014209172);河北省中医药管理局项目(2014186); 唐山市科技支撑项目(14130221a);华北理工大学博士科研启动基金(35757199) 收稿日期: 2016 - 03 - 14 作者简介: 徐丁洁(1984-),女,山东临沂人,医学博士,讲师,研究方向:妇科寒证。E-mail:xudingjie@163.com
更新日期/Last Update: 2016-03-20