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复方甘草酸苷联合卡介菌多糖核酸治疗斑秃44例临床观察(PDF)

《云南中医学院学报》[ISSN:1000-2723/CN:53-1048/R]

期数:
2016年03期
页码:
77-79
栏目:
临床研究
出版日期:
2016-05-15

文章信息/Info

Title:
Curative Effect Observation of 45 Cases Alopecia Areata Treated by Card Interface Polysacchairides Nucleic Acid Combined with Compound Glycyrrhizin
作者:
郑慧1夏道宗2邓新杰1
1. 浙江中医药大学附属衢州中心医院,浙江 衢州 324000;2. 浙江中医药大学药学院,浙江 杭州 310000
Author(s):
ZHENG Hui1 XIA Daozong2 DENG Xinjie1
1. Quzhou Center Hospital Affillated to Zhejiang Chinese Medical University, Quzhou 324000, China;2. College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310000, China
关键词:
斑秃 复方甘草酸苷 Thl/Th2 卡介菌多糖核酸 米诺地尔
Keywords:
alopecia areata compound glycyrrhizin Thl/Th2 polysaccharide nucleic acid of Bacillus Calmette-guerin minoxidil
分类号:
R758.71
DOI:
10.19288/j.cnki.issn.1000-2723.2016.03.019
文献标识码:
A
摘要:
目的探讨复方甘草酸苷联合卡介菌多糖核酸治疗斑秃的临床疗效。方法观察组口服复方甘草酸苷,联合肌肉注射卡介菌多糖核酸及外用5%米诺地尔酊;对照组只是肌肉注射卡介菌多糖核酸及外用5%米诺地尔酊;共治疗3个月,观察2组不同药物使用后对病情的改善情况。结果观察组的有效率及治愈率均显著高于对照组,观察组和对照组的有效率分别是90.9%和70.7%(P<0.01)治愈率分别是50.0%和39.0%(P<0.05)。结论复方甘草酸苷联合卡介菌多糖核酸治疗斑秃疗效确切,副作用少。
Abstract:
Objective To observe the effect and safety of polysaccharide nucleic acid of Bacillus Calmette-guerin combined with compound glycyrrhizin in treatment of alopecia areata. Patients were divided into 2 groups. Methods 45 patients in treatment group were treated with polysaccharide nucleic acid of Bacillus Calmette-guerin 2mL every other day, combined with compound glycyrrhizin 50mg 3 times per day. 44 patients in the control group with were treated with compound glycyrrhizin 50mg 3 times per day. All patients were treated with Minoxidil tincture. The course lasted for twelve weeks, and adverse effects were observed between these two groups. Results After twelve weeks treatment, the total response rates of the treatment group and control group effective rates were 90.9% and 70.7%, comparision among the two group was significantly different. Conclusion Polysaccharide nucleic acid of Bacillus Calmette-guerin combined with compound glycyrrhizin in treatment of alopecia areata has a good efficiency and high safety.

参考文献/References

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备注/Memo

备注/Memo:
* 基金项目: 国家自然科学基金(81374048) 收稿日期: 2016 - 03 - 07 作者简介: 郑慧(1988-),女,浙江衢州人,在读硕士研究生,研究方向:中药药理学。△通信作者:夏道宗,E-mail:xiadaozong@zcmu.edu.cn
更新日期/Last Update: 2016-05-20