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III-IV期结、直肠癌中医证型与p16蛋白表达的相关性研究(PDF)

《云南中医学院学报》[ISSN:1000-2723/CN:53-1048/R]

期数:
2016年03期
页码:
84-86
栏目:
临床研究
出版日期:
2016-05-15

文章信息/Info

Title:
Relationship between TCM Syndrome Types of III-IV and p16 Protein Expression in Colorectal Cancer
作者:
谢晓平1林阿丰2陈晓帆2
1. 福建省三明职业技术学院,福建 三明 365000;2. 福建医科大学附属三明第一医院,福建 三明 365000
Author(s):
XIE Xiaoping1 LIN Afeng2 CHEN Xiaofan2
1. Sanming Vocational Technical College, Sanming 365000, China;2. The First Affiliated Hospital of Fujian Medical University, Sanming 365000, China
关键词:
晚期结、直肠癌 中医辨证分型 p16蛋白 免疫组化
Keywords:
advanced colorectal cancer TCM syndrome differentiation and typing p16 protein immuno histochemistry
分类号:
R273
DOI:
10.19288/j.cnki.issn.1000-2723.2016.03.021
文献标识码:
A
摘要:
目的研究p16蛋白表达与III-IV期结、直肠癌中医辨证分型的相关性。方法应用免疫组化染色法检测正常组织及III-IV期结、直肠癌p16的表达,对III-IV期结、直肠癌进行辨证分型,将其中医证型和p16的表达的相关性进行分析。结果①正常对照组中p16蛋白表达水平明显高于III-IV期结、直肠癌组织,差异有统计学意义(P<0.05),且随着病理分期的进展,其差异明显增加。② III-IV期结、直肠癌中医辨证分型与p16蛋白表达存在相关性,差异有统计学意义(P<0.05)。结论① p16蛋白表达的缺失与结、直肠癌的发生发展有关,p16蛋白表达的缺失可作为临床评估结、直肠癌生物学行为和判断预后的指标。② p16蛋白表达在不同中医证型的III-IV期结、直肠癌中存在一定的差异。
Abstract:
Objective To study the correlation between the expression of p16 protein and TCM syndrome differentiation type of III-IV phase and rectal cancer. Methods The expression of p16 in normal tissues and III-IV in colorectal carcinoma was detected by immunohistochemical staining, differentiation and typing of III-IV phase and rectal carcinoma, the correlation between TCM syndrome types and the expression of p16 was analyzed. Results 1. The expression level of p16 in the normal control group was significantly higher than that in the III-IV phase and colorectal carcinoma tissues, the difference was statistically significant(P<0.05), and with the progress of pathological staging, the difference was significantly increased. 2. Correlation between TCM syndrome differentiation type of III-IV and p16 protein expression in colorectal cancer, the difference was statistically significant(P<0.05). Conclusion 1. The loss of p16 protein expression is related to the occurrence and development of colorectal cancer, the loss of p16 protein expression can be used as an index to evaluate the biological behavior and prognosis of colorectal cancer. 2. p16 protein expression in different TCM syndrome types of III-IV stage, there are some differences in colorectal cancer.

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备注/Memo

备注/Memo:
* 基金项目: 福建省教育厅中青年教师教育科研项目(JB14200) 收稿日期: 2016 - 04 - 05 作者简介: 谢晓平(1979-),女,福建惠安人,讲师,研究方向:中西医结合肿瘤消化内科。E-mail:mary197910@126.com
更新日期/Last Update: 2016-05-20