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|本期目录/Table of Contents|

微小RNA在糖尿病足溃疡发病及愈合过程中的研究进展(PDF)

《云南中医学院学报》[ISSN:1000-2723/CN:53-1048/R]

期数:
2016年03期
页码:
95-98
栏目:
综述
出版日期:
2016-05-15

文章信息/Info

Title:
Research Progress of MicroRNA in the Pathogenesis and Healing of Diabetic Foot Ulcer
作者:
李文惠柳国斌△黄海
上海中医药大学附属曙光医院,上海 201203
Author(s):
LI Wenhui LIU Guobin HUANG Hai
Shanghai Shuguang Hospital Affiliated with Shanghai University of TCM, Shanghai 201203, China
关键词:
miRNA 糖尿病足溃疡 发病机制 愈合 治疗进展
Keywords:
microRNA diabetic foot ulcer pathogenesis healing treatment progress
分类号:
R587.2
DOI:
10.19288/j.cnki.issn.1000-2723.2016.03.024
文献标识码:
A
摘要:
微小RNA(microRNA,miRNA)是一类长度约为20-24个核苷酸的具有调控功能的非编码RNA,在人体中主要通过抑制miRNA翻译来调节人类约30%的编码蛋白,进而调节一系列生物学过程,包括生物体生长、发育和疾病等。研究表明,miRNA在糖尿病及其并发症发生发展等过程中发挥重要作用,已成为调节生物学过程的核心因子。糖尿病溃疡是糖尿病常见并发症,已有大量证据证实miRNA在糖尿病溃疡发生及愈合过程中发挥重要作用。本文就糖尿病足发病过程中对神经及微血管的损害及其溃疡愈合中各环节中的相关miRNA作用作一综述。
Abstract:
MiRNA is the non-coding RNA which length about 20-24 nucleotides with the function of regulating, inhibiting mRNA translation to regulate the nearly 30% of all human protein encoding in the human body, it can regulate a variety of biological processes, including the organism growth, development and disease. Studies have indicated that miRNA plays an important role in the development of diabetes and its complications, and it has become a key factor in the regulation of biological processes. Diabetic ulcer is the most common complications of diabetes, there are amounts of evidences in the generating and healing process that miRNA counts a lot in the diabetic ulcer. In this paper, we overview of related miRNA function of nerve and vascular damage, and ulcer healing process in the pathogenesis of diabetic foot.

参考文献/References

[1] 李峥璟,柏素萍,孙炳伟. 糖尿病溃疡形成机制的研究进展[J]. 江苏大学学报(医学版),2012,22(4):363-366.
[2] Boulton AJ. The diabetic foot:from art to science. The 18th Camillo Golgi lecture[J]. Diabetologia,2004,47:1343-1353.
[3] 郑玲,刘秋爽,金晶,等. 糖尿病并发症治疗靶点的研究进展[J]. 海峡药学,2014,26(1):13-17.
[4] Armstrong DG,Kanda VA,Lavery LA,et al. Mind the gap:the disparity between research funding and costs of care for diabetic foot ulcers[J]. Diabetes Care,2013,36(7):1815-1817.
[5] Hinchliffe RJ,Andros G,Apelqvist J,et al. A systematic review of the effectiveness of revascularization of the ulcerated foot in patients with diabetes and peripheral arterial disease[J]. Diabetes Metab Res Rev,2012,28(S 1):179-217.
[6] 倪桂莲,崔融,陈干明,等. 糖尿病大鼠背根神经节JNK 的表达水平对足部皮肤组织学变化的影响[J]. 中国病理生理杂志,2015,31(3):415-420.
[7] Eilers A,Whitfield J, Shah B,et a1. Direct inhibition of c-jun N-terminal kinase in sympathetic neuronsprevents c-jun promoter activation and NGF withdrawal induced death[J]. J Neurochem,2001,76(5):1439-1454.
[8] Wang L,Chopp M,Szalad A,et a1. The role of miR-146a in dorsal root ganglia neurons of experimental diabetic peripheral neuropathy[J]. Neuroscience,2014,259:155-163.
[9] Togliatto G,Trombetta A,Dentelli P,et al. MIR221/MIR222- driven post-transcriptional regulation of P27KIP1 and P57KIP2 is crucial for high-glucose-and AGE-mediated vascular cell damage[J]. Diabetologia,2011,54(7):1930-1940.
[10] Loomans CJ,de Koning EJ,Staal FJ,et al. Endothelial progenitor cell dysfunction:a novelconcept in the pathogenesis of vascular complications of type 1 diabetes[J]. Diabetes, 2004,53:195-199.
[11] Tepper OM,Galiano RD,Capla JM,et al. Human endothelial progenitor cells from type IIdiabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures[J]. Circulation,2002,106(22):2781-2786.
[12] Meng S,Cao JT,Zhang B,et al. Downregulation of microRNA-126 in endothelial progenitor cells from diabetes patients,impairs their functional properties,via target gene Spred-1[J]. J Mol Cell Cardiol,2012,53(1):64-72.
[13] Caporali A,Meloni M,Vollenkle C,et al. Deregulation of microRNA-503 contributes to diabetes mellitus-Induced impairment of endothelial function and reparative angiogenesis after limb ischemia[J]. Circulation,2011,123(3):282-291.
[14] Li Y,Song YH,Li F,et al. MicroRNA-221 regulates high glucose-induced endothelial dysfunction[J]. Biochem Biophys Res Commun,2009,381(1):81-83.
[15] Reddy MA,Jin W,Villeneuve L,et al. Pro-inflammatory role of microrna-200 in vascular smooth muscle cells from diabetic mice[J]. Arterioscler Thromb Vasc Biol,2012,32(3):721-729.
[16] McArthur K,Feng B,Wu Y,et al. MicroRNA-200b regulates vascular endothelial growth factor–mediated alterations in diabetic retinopathy[J]. Diabetes,2011,60(4):1314-1323.
[17] Gurtner GC,Werner S,Barrandon Y,et al. Wound repair and regeneration[J]. Nature,2008,453(7193):314-321.
[18] 刘移峰,刘德伍,毛远桂,等. 糖尿病创面与正常创面微小RNA差异表达谱分析[J]. 中华实验外科杂志,2015,32(1):57-59.
[19] Sundaram G M,Common J E,Gopal F E,et al. ‘See-saw’expression of microRNA-198 and FSTL1 from a single transcript in wound healing[J]. Nature,2013,495(7439):103-106.
[20] 陆君. 慢性炎症与2型糖尿病[J]. 实用心脑肺血管病杂志,2006,14(8):600-602.
[21] Xu J,Wu W,Zhang L,et al. The role of microRNA-146a in the pathogenesis of the diabetic wound-healing impairment:correction with mesenchymal stem cell treatment[J]. Diabetes,2012,61(11):2906-2912.
[22] Dangwal S,Stratmann B,Bang C,et al. Impairment of Wound Healing in Patients With Type 2 Diabetes Mellitus Influences Circulating MicroRNA Patterns via Inflammatory Cytokines[J]. Arterioscler Thromb Vasc Biol,2015,35(6):1480-1488.
[23] Stanczyk J,Pedrioli DM,Brentano F,et al. Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis[J]. Arthritis Rheum,2008,58(4):1001-1009.
[24] Kishore R,Verma SK,Mackie AR,et al. Bone marrow progenitor cell therapy-mediated paracrine regulation of cardiac miRNA-155 modulates fi brotic response in diabetic hearts[J]. PLoS One,2013,8(4):e60161.
[25] Wang S,Aurora AB,Johnson BA,et al. The endothelial-specific microRNAmiR-126 governs vascular integrity and angiogenesis[J]. Dev Cell,2008,15(2):261-271.
[26] Epis MR,Giles KM,Kalinowski FC,et a1. Regulation of expression of deoxyhypusine hydroxylase(DOHH),the enzyme that catalyzes the activation of elF5A,by miR-33l-3p and miR-642-5p in prostate cancer cells[J]. J Biol Chem,2012,287(42):35251-35259.
[27] Wang K,Long B,Jiao JQ,et a1. miR-484 regulates mitochondfial net—work through targeting Fisl[J]. Nat Commun,2012,3:781.
[28] Zampetaki A,Kiechl S,Drozdov I,et al. Plasma microRNA profi ling reveals loss of endothelial miR-126 and other microRNAs in type 2 Diabetes[J]. Circ Res,2010,107(6):810-817.
[29] Cottonham CL,Kaneko S,Xu L. miR-21 and miR-31 converge on TIAM1 to regulate migration and invasion of colon carcinom a cells[J]. J Biol Chem,2010,285(46):35293-35302.
[30] Madhyastha R,Madhyastha H,Nakajima Y,et al. MicroRNA signature in diabetic wound healing:promotive role of miR-21 in fibroblast migration[J]. Int Wound J,2012,9(4):355-361.
[31] Maurer B,Stanczyk J,Jüngel A,et al. MicroRNA-29,a key regulator of collagen expression in systemic sclerosis[J]. Arthritis Rheum,2010,62(6):1733-1743.
[32] He A,Zhu L,Gupta N,et al. Overexpression of micro ribonucleic acid 29,highly up-regulated in diabetic rats,leads to insulin resistance in 3T3-L1 adipocytes[J]. Mol Endocrinol,2007,21(11):2785-2794.

备注/Memo

备注/Memo:
* 基金项目: 上海市科学技术委员会科研计划项目(10DZ1972800);上海市科学技术委员会科研计划项目(12401903800); 上海市中医药事业发展三年行动计划项目(ZYSNXD-CC-ZDYJ055);上海市浦东新区重点学科群建设资 助项目(PWZxkq2010-04) 收稿日期: 2016 - 04 - 16 作者简介: 李文惠(1989-),女,山东青岛人,在读博士研究生,研究方向:中西医结合治疗周围血管疾病。△通信作者:柳国斌,E
更新日期/Last Update: 2016-05-20