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|本期目录/Table of Contents|

益肾化浊法对多发梗塞性痴呆大鼠学习记忆力的影响(PDF)

《云南中医学院学报》[ISSN:1000-2723/CN:53-1048/R]

期数:
2016年04期
页码:
6-10
栏目:
实验研究
出版日期:
2016-08-01

文章信息/Info

Title:
Influence of Yishen Huazhuo Method on Learning and Memory Ability in Dementia Rats due toMultiple Cerebral Infarction
作者:
陈婷婷谢颖桢△
北京中医药大学东直门医院,北京 100029
Author(s):
CHEN Tingting XIE Yingzhen
Dongzhimen Hospital to Beijing University of Chinese Medicine, Beijing 100029, China
关键词:
血管性痴呆 益肾化浊法 Morris水迷宫
Keywords:
vascular dementia Yishen Huazhuo method Morris water labyrinth
分类号:
R285.5
DOI:
10.19288/j.cnki.issn.1000-2723.2016.04.002
文献标识码:
A
摘要:
目的研究益肾化浊法(复方苁蓉益智胶囊)对多发梗塞性痴呆大鼠学习与记忆能力的作用。方法选择多发梗塞性痴呆大鼠模型,分为给药组和模型组,另设假手术组,治疗组提前3d给药,运用morris水迷宫评价大鼠认知能力,HE染色评价模型病理结果。结果①在Morris水迷宫隐匿平台训练中,从第3次训练3组开始出现差异,假手术组的逃避潜伏期最短,治疗组的逃避潜伏期比模型组明显缩短,第5次训练3组相当,模型组学习记忆时间明显延长。②探索试验中假手术组穿越平台次数最多,治疗组穿越平台次数显著多于模型组。结论益肾化浊法可显著改善痴呆大鼠记忆学习能力。
Abstract:
Objective To resarch the influence of Yishen Huazhuo method on learning and memory ability in dementia rats due to Multiple cerebral infarction. Methods Select the model of dementia rats due to multiple cerebral infarction, divided into the administration group, the model group and the false surgery group, give drug to the administration group 3 days in advance. Use water morris labyrinth to evaluate the rats’ cognitive, use the method of HE staining to evaluate the pathology results. Results ①In the training of the morris water labyrinth of misprision of platforms, At the third training, the three groups begin to vary, For the incubation period of escape, false operating team use the shortest time, and the administration group use more shorter time than the model group. The three groups use the same time in the Fifth Train, but the model group takes more times for learning. ②In the exploration temp, the false surgery group cross platform most times The number of treatment group across platforms significantly more than model group. Conclusion The method of Yishen Huazhuo can dramatically improve the dementia rats’ memory and learning ability.

参考文献/References

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备注/Memo

备注/Memo:
* 基金项目: 国家中医药管理局中医脑病重点学科;王永炎“3+3”薪火传承工作室 收稿日期: 2016 - 04 - 20 作者简介: 陈婷婷(1986-),女,山东济宁人,主治医师,在读博士研究生,研究方向:中医药防治脑血管疾病。△通信作者:谢颖桢,E-mail:xyz_3191@aliyun.com
更新日期/Last Update: 2016-07-20