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除湿通痹方对急性痛风性关节炎小鼠抗炎镇痛的作用研究(PDF)

《云南中医学院学报》[ISSN:1000-2723/CN:53-1048/R]

期数:
2016年04期
页码:
16-19
栏目:
实验研究
出版日期:
2016-08-01

文章信息/Info

Title:
Effects of the Gout One Prescription on Anti-inflammatory in Rats with Acute Gouty Arthritis
作者:
王涛1廖江龙1艾元亮1许燕飞1邱发敏2徐平2温辉2黄文泽2李雷1
1. 昆明市中医医院,云南 昆明 650011;2. 云南中医学院,云南 昆明 650021
Author(s):
WANG Tao1 LIAO Jianglong1 AI Yuanliang1 XU Yanfei1 QIU Famin2 XU Ping2WEN Hui2 HUANG Wenze2 LI Lei1
1. Kunming Municipal Hospital of Traditional Chinese Medicine, Kunming 650011, China;2. Yunnan University of Traditional Chinese Medicine, Kunming 650021, China
关键词:
急性痛风性关节炎 除湿通痹方 抗炎 镇痛
Keywords:
acute gouty arthritis gout one prescription anti-inflammatory analgesic
分类号:
R285.5
DOI:
10.19288/j.cnki.issn.1000-2723.2016.04.004
文献标识码:
A
摘要:
目的探讨除湿通痹方的抗炎、镇痛作用,为临床治疗急性痛风性关节炎提供实验依据。方法通过二甲苯涂抹制备小鼠耳廓肿胀模型及采用醋酸致小鼠腹腔毛细血管通透性实验,观察除湿通痹方的抗炎作用;通过醋酸法和热板法致小鼠实验性疼痛模型,观察除湿通痹方的镇痛作用。结果除湿通痹方Ⅱ组、Ⅲ组对小鼠耳肿胀有明显的抑制作用(P<0.05,P<0.01);除湿通痹方Ⅱ组、Ⅲ组能显著抑制醋酸所致的小鼠腹腔毛细血管通透性增高(P<0.01);除湿通痹方I组、Ⅱ组、Ⅲ组对醋酸所致小鼠扭体模型中有一定的镇痛作用(P<0.01),且存在剂量依赖性;除湿通痹方Ⅱ组、Ⅲ组在给药后30、60、90、120min均能延长小鼠痛反应潜伏期(P<0.05,P<0.01),其痛阈提高率在25%以上。结论除湿通痹方具有明显的抗炎、镇痛作用,可用于急性痛风性关节炎的治疗。
Abstract:
Objective To investigate the anti-inflammatory and analgesic of the gout one prescription, and to improve the experimental evidence for clinical treatment of acute gout arthritis. Methods We need to prepare to ear swelling model of rats by xylene and the capillary permeability induced by acetic acid of rats, to observe the anti-inflammatory effect of the gout one prescription;the experimental pain model of rats induced by acetic acid and hot pate method was used to observe the analgesic effect of the gout one prescription. Results The effect of Ⅱgroup and Ⅲ group of the gout one prescription on the ear swelling of rats was significantly inhibited(P<0.05, P<0.01);the increasing of the peritoneal capillary permeability in mice induced by acetic acid was significantly inhibited by Ⅱgroup and Ⅲ group of the gout one prescription(P<0.01);the analgesic effect of I group、Ⅱgroup and Ⅲ group of the gout one prescription on the mouse torsion model induced by acetic acid was significant(P<0.01), and the analgesic effect of I group、Ⅱgroup and Ⅲ group of the gout one prescription has dosage dependence;30minutes, 60minutes, 90minutes, 120 minutes after given by Ⅱgroup and Ⅲ group of the gout one prescription, its incubation period of pain response in mice was prolonged(P<0.05, P<0.01), and the pain threshold was increased at a rate above 25%. Conclusion The gout one prescription has a demonstrable effect on anti-inflammatory and analgesic, and it can be used for the treatment of acute gout arthritis.

参考文献/References

[1] 王莎莎,沈鹰. 痹证三方镇痛抗炎消肿作用的实验研究[J]. 四川中医,2012,30(10):38-41.
[2] 陈奇. 中药药理研究方法学[M]. 北京:人民卫生出版社,1996:34.
[3] 李江,罗昱澜,童东锡,等. 三叶青藤醇提物对小鼠腹腔毛细血管通透性的影响[J]. 华夏医学,2013,26(1):9-10.
[4] 黄敬群,宋扬,赵鹏,等. 槲皮素对急性痛风性关节炎的抗炎、镇痛实验研究[J]. 海峡药学,2013,25(7):64-67.
[5] 刘文萍. 三七总皂苷的抗炎镇痛作用及其配伍对CIA大鼠滑膜RANKL/OPG表达的影响[D]. 石家庄:河北医科大学,2014.
[6] 向彬,杨杰,周春花,等. 点地梅的抗炎镇痛作用研究[J]. 中国医药科学,2014,4(3):31-33.
[7] 党晓芬. 王不留行抗炎、镇痛活性部位筛选及其作用机制研究[D]. 西安:陕西师范大学,2014.
[8] 王长林,王秀君,浦仕飞. 荆芥与防风的药理作用试验研究[J]. 郑州牧业工程高等专科学校学报,2009,29(1):6-8.
[9] 金玉青,洪远林,李建蕊,等. 川芎的化学成分及药理作用研究进展[J]. 中药与临床,2013,4(3):44-48.
[10] 姜萍,王占奎. 清泻浊毒法对高尿酸血症大鼠尿量及尿酸水平的影响[J]. 世界中西医结合杂志,2013,8(6):605-607.
[11] 陈光亮,吕红霞,王媛媛,等. 萆薢牛膝总皂苷对尿酸钠诱导的大鼠急性痛风性关节炎的防治作用[J]. 中药药理与临床,2010,26(1):34-37.
[12] 王春玲. 中药地龙的活性成分与药理作用研究[J]. 亚太传统医药,2015,11(7):53-54.
[13] 刘洪超,杨小龙,王淑英. 猪苓药理作用研究进展[J]. 河南科技大学学报(医学版),2011,29(2):159-160.
[14] 李婷,徐文珊,李西文,等. 中药桔梗的现代药理研究进展[J]. 中药药理与临床,2013,29(2):205-208.

备注/Memo

备注/Memo:
* 基金项目: 云南省应用基础研究计划项目(201401SH00018);云南省科技计划项目(2013FD099) 收稿日期: 2016 - 04 - 12 作者简介: 王涛(1984-),男,云南昆明人,主治医师,研究方向:中西医结合骨伤科基础与临床。△通信作者:李雷,E-mail:183070775@qq.com
更新日期/Last Update: 2016-07-20