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|本期目录/Table of Contents|

补肾活血中药治疗早中期股骨头坏死的系统评价与Meta分析*(PDF)

《云南中医学院学报》[ISSN:1000-2723/CN:53-1048/R]

期数:
2019年01期
页码:
47-54
栏目:
临床研究
出版日期:
2019-10-29

文章信息/Info

Title:
Systematic Review and Meta-analysis of Bushen Huoxue Chinese Medicine in the Treatment of Early and Middle Femoral Head Necrosis
文章编号:
1000-2723(2019)01-0047-08
作者:
石淇允12李无阴2△张颖2田涛涛2张来福2谭旭仪3王浩翔1段嘉豪1
(1. 湖南中医药大学,湖南 长沙 410208;2. 河南省洛阳正骨医院/河南省骨科医院,河南 洛阳 471002;3. 湖南中医药研究院,湖南 长沙 410006)
Author(s):
SHI Qiyun12 LI Wuyin2 ZHANG Ying2 TIAN Taotao2 ZHANG Laifu2 TAN Xuyi3 WANG Haoxiang1 DUAN Jiahao 1
(1. Hunan University of Chinese Traditional Medicine, Changsha 410208, China;2. Luoyang Orthopedic Hospital of Henan Province/Orthopedic Hospital of Henan Province, Luoyang 471002, China;3. Affiliated Hospitalof Hunan Academy of Chinese Medical Science, Changsha 410006, China)
关键词:
股骨头坏死 补肾活血法 中药 系统评价 随机对照试验 Meta分析
Keywords:
femoral head necrosis Bushen Huoxue method traditional Chinese medicine systematic evaluation randomized controlled trial(RCT)meta-analysis
分类号:
R274.9
DOI:
10.19288/j.cnki.issn.1000-2723.2019.01.010
文献标识码:
A
摘要:
目的评价补肾活血类中药治疗早中期股骨头坏死的有效性和安全性。方法系统检索医学常用英文数据库(PubMed,Cochrane Library,Clinical trials.gov)及中文数据库(CNKI、万方、VIP、CBM)共7个,按照拟定的纳入标准与排除标准进行筛选,将文献按照Cochrane Handbook for Systematic Reviews of Interventions进行质量评估,并运用Rev Man 5.3软件进行Meta分析。结果共检索到文献1 542篇,筛选后纳入文献11篇,其中中文文献9篇,外文文献2篇。研究显示中药补肾活血法能够改善早中期股骨头坏死患者的临床有效率、Harris评分及血液流变学指标。结论根据现有文献显示,中药补肾活血法治疗早中期股骨头坏死具有一定的疗效,且效果优于西药,但是所纳入的文献都存在一定程度的选择偏倚,从而影响结果的论证强度,而结论的可靠性还需要进一步大样本多中心的试验研究来证实。
Abstract:
Objective To evaluate the efficacy and safety of Bushen Huoxue traditional Chinese medicine n the treatment of early and middle femoral head necrosis. Methods A total of 7 commonly used English databases (PubMed, Cochrane Library, Clinical trials.gov) and Chinese databases(CNKI, Wanfang, VIP, CBM) were searched, and the literature was selected according to the proposed inclusion criteria and exclusion criteria. The Cochrane Handbook for Systematic Reviews of Interventions was evaluated for quality and meta-analysis was performed using Rev Man 5.3 software. Results A total of 1542 articles were retrieved, and 11 articles were included in the screening, including 9 Chinese articles and 2 foreign literatures. Studies have shown that Chinese medicine Bushen Huoxue method can improve the clinical efficiency, Harris score and hemorheology of patients with early and middle femoral head necrosis. Conclusion According to the existing literature, traditional Chinese medicine Bushen Huoxue therapy has certain curative effect on early and middle femoral head necrosis, and its effect is better than western medicine, but the included literature has a certain degree of selection bias, which affects the strength of the argument. The reliability of the conclusions needs further confirmation with a large sample of multicenter trials.

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备注/Memo

备注/Memo:
收稿日期: 2019 - 01- 17
* 基金项目: 国家自然科学基金面上项目(81874477,81774348);河南省中医药科学研究专项课题(2016ZY1010)
第一作者简介: 石淇允(1994-),男,在读硕士研究生,研究方向:中医药防治骨与关节损伤疾病。
△通信作者: 李无阴,E-mail:hnlc.lwy@gmail.com
更新日期/Last Update: 2019-10-22