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中风后痉挛性瘫痪现代文献用药规律分析*(PDF)

《云南中医学院学报》[ISSN:1000-2723/CN:53-1048/R]

期数:
2019年02期
页码:
78-82
栏目:
方药研究
出版日期:
2019-11-15

文章信息/Info

Title:
Medication Rule Analysis of Modern Literature in Post-stroke Spasticity
文章编号:
1000-2723(2019)02-0078-05
作者:
谢 乐1曹思佳2伍大华1△毛 果1
(1. 湖南省中医药研究院附属医院脑病科,湖南 长沙410006;2.湖南中医药大学人文与管理学院,湖南 长沙,410208)
Author(s):
XIE Le1 CAO Sijia2 WU Dahua1 MAO Guo1
(1. Neurology Department, the Affiliated Hospital of Hunan Academy of Chinese Medicine, Changsha 410006, China; 2. School of Humanities and Management, Hunan University of Chinese Medicine, Changsha 410208, China)
关键词:
中风后痉挛性瘫痪 用药规律 因子分析 聚类分析
Keywords:
post-stroke spasticity medication rule factor analysis cluster analysis
分类号:
R277.7
DOI:
10.19288/j.cnki.issn.1000-2723.2019.02.016
文献标识码:
A
摘要:
目的搜集1979年以来正式发表的关于中风后痉挛性瘫痪的文献,对其用药规律进行探索,为临床治疗中风后痉挛性瘫痪提供理论依据。方法 采用EpiData 3.1建立中风后痉挛性瘫痪现代文献数据库,SPSS 20.0对其进行频数分析、因子分析、聚类分析等,挖掘其用药规律。结果 共纳入文献107篇,涉及方68首,药物129味,用药总频次为1 078次。得到累计使用频次大于75%的高频药物28味,其中使用频次最多的药物为白芍,最主要使用的药类为活血化瘀药及补血药,因子分析得到10个公因子,聚类分析得到4个聚类组。结论 中风后痉挛性瘫痪基本病机可以分为阴血亏虚、络脉瘀阻,气血亏虚、络脉瘀阻,血虚筋脉失养3大类,白芍是治疗中风后痉挛性瘫痪的最主要药物,木瓜、伸筋草、鸡血藤为对症治疗痉挛的主要药物。
Abstract:
Objective Collected published literature about the post-stroke spasticity since 1979 to explore the medication rule post-stroke spasticity. Methods EpiData 3.1 was adopted to establish the database of post-stroke spasticity, frequency analysis, factor analysis and cluster analysis were performed by SPSS 20.0. Results A total of 107 articles were included, involving 68 prescriptions, 129 drugs, and the total frequency of the drugs was 1 078 times. There were high frequency drugs 28, and the most frequently used drugs were Radix Paeoniae Alba, the major used drugs were drugs of invigorating the circulation of blood and drugs of enriching the blood. 10 common factors were obtained by factor analysis and four groups were obtained by cluster analysis. Conclusion Yinxuekuixu, luomaiyuzu, Qixuekuixu, luomaiyuzu and Xuexujin-maishiyang are the principal syndromes of post-stroke spasticity. Radix Paeoniae Alba is the most important drug for the treatment of post-stroke spasticity. Papaya, Lycopodium clavatum, Millettia are the mainly symptomatic treatment drugs.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期: 2019 - 03- 13
* 基金项目: 湖南省自然科学基金青年基金项目(2019JJ50343);湖南省中医药管理局项目(201938);湖南省中医药研究院 院级重点课题(201801)
第一作者简介: 谢乐(1988-),男,博士,主治医师,研究方向:脑病的中医药防治。
△通信作者: 伍大华,E-mail:893049352@qq.com
更新日期/Last Update: 2019-11-19