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|本期目录/Table of Contents|

疏肝法治疗癫痫的系统评价和Meta分析*(PDF)

《云南中医学院学报》[ISSN:1000-2723/CN:53-1048/R]

期数:
2019年06期
页码:
33-38
栏目:
临床研究
出版日期:
2020-06-15

文章信息/Info

Title:
Systematic Review and Meta-analysis of the Efficacy of Soothing Liver Method in the Treatment of Epilepsy Disease
文章编号:
1000-2723(2019)06-0033-06
作者:
袁敏皎1韩祖成2△袁 捷2
(1. 陕西中医药大学,陕西 咸阳 712000;2. 陕西省中医医院,陕西 西安 710000)
Author(s):
YUAN Minjiao1 HAN Zucheng2 YUAN Jie2
(1. Shaanxi University of Chinese Medicine, Xianyang 712000, China; 2. Shaanxi Hospital of Traditional Chinese Medicine, Xi’an 710000, China)
关键词:
疏肝法癫痫临床疗效系统评价Meta分析随机对照试验
Keywords:
Liver-soothing method Epilepsy clinical efficacy systematic review Meta analysis randomized controlled trial
分类号:
R277.7
DOI:
10.19288/j.cnki.issn.1000-2723.2019.06.006
文献标识码:
A
摘要:
目的该文章采用Meta分析方法评价疏肝法治疗癫痫的疗效和安全性。方法 通过计算机全面检索Cochrane Library、PubMed、万方数据库、维普、中国知网(CNKI)中符合条件的随机对照临床试验,检索时限为建库至2019年12月,获得相关数据后,通过使用 RevMan 5.3软件进行Meta分析。结果 本文纳入随机对照试验8项,共670例患者,其中试验组341例,对照组329例。疏肝法联合抗癫痫药物治疗癫痫的Meta分析结果显示其临床疗效优于单纯使用抗癫痫药物,脑电图改善率、发作频次、QOL-31(癫痫患者生活质量评定量表)等结局指标与对照组相比均改善明显,差异有统计学意义(P<0.05);且相比于西医常规治疗癫痫,疏肝法治疗癫痫的不良反应较少。结论 疏肝法联合抗癫痫药物治疗癫痫的临床疗效明显,且不良反应少。但由于目前纳入研究的质量不高,此结论尚需更多高质量研究进行验证。
Abstract:
Objective To evaluates the efficacy and safety of soothing liver method in the treatment of epilepsy by Meta-analysis. Methods A computerized search of eligible randomized controlled clinical trials in the Cochrane Library, PubMed, Wanfang Database, Weipu, and China Knowledge Network(CNKI) was performed. The search period was from the establishment of the database to December 2019. After obtaining relevant data,Meta analysis was conducted using RevMan 5.3 software. Results Eight randomized controlled trials were included in this article, with a total of 670 patients, including 341 in the test group and 329 in the control group. The results of Mate analysis of soothing liver method combined with antiepileptic drugs for epilepsy show that its clinical efficacy is better than that of antiepileptic drugs alone. Compared with the control group, EEG improvement rate, frequency of seizures, and quality of life of patients with epilepsy(QOL-31) were significantly improved, and the difference was statistically significant (P<0.05). Compared with the conventional treatment of epilepsy in western medicine, Liver-soothing method had fewer adverse reactions in the treatment of epilepsy. Conclusion Liver-soothing method combined with antiepileptic drugs has excellent clinical efficacy in treating epilepsy, and has few adverse reactions. However, due to the low quality of the included studies, this conclusion needs to be verified by more high-quality studies.

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备注/Memo

备注/Memo:
收稿日期: 2019 - 12- 02
* 基金项目: 国家中医药管理局中医药行业科研专项(201507001-05);陕西省中医药管理局长安中风病刚柔相济流派 传承工作室(陕中医药发[2018]40号); 陕西省中医药管理局失眠症阴阳序贯证治研究室(陕中医药发[2018] 32号);陕西省中医医院院级科研课题 (2019-02)
第一作者简介: 袁敏皎(1992-),女,在读硕士研究生,研究方向:脑病基础与临床。
△通信作者: 韩祖成,E-mail: 13759968645@139.com
更新日期/Last Update: 2020-06-30