我们的网站为什么显示成这样?

可能因为您的浏览器不支持样式,您可以更新您的浏览器到最新版本,以获取对此功能的支持,访问下面的网站,获取关于浏览器的信息:

|本期目录/Table of Contents|

基于芳香温通法探讨中医药治疗冠心病用药规律*(PDF)

《云南中医学院学报》[ISSN:1000-2723/CN:53-1048/R]

期数:
2019年06期
页码:
79-83
栏目:
方药研究
出版日期:
2020-06-15

文章信息/Info

Title:
Study on the Law of Traditional Chinese Medicine in Treating Coronary Heart Disease Based on Aromatherapy Method
文章编号:
1000-2723(2019)06-0079-05
作者:
闫海峰1杨志华1王 琳1姬艳苏2王淑萍2△
(1. 天津中医药大学第一附属医院,天津 300381;2. 武警特色医学中心,天津 300162)
Author(s):
YAN Haifeng1 YANG Zhihua1 WANG Lin1 JI Yansu2 WANG Shuping2△
(1.First Teaching Hospital of Tianjin University of TCM, Tianjin 300381, China 2. Characteristic Medical Center of PAP, Tianjin 300162, China)
关键词:
芳香温通法中医药冠心病:用药规律
Keywords:
aromatherapy method traditional Chinese medicinecoronary heart disease medication laws
分类号:
R289.1;R259
DOI:
10.19288/j.cnki.issn.1000-2723.2019.06.013
文献标识码:
A
摘要:
使用国家专利网、中国知网(CNKI)筛选出基于芳香温通法治疗冠心病的中成药及中医处方56首,运用中医传承辅助平台系统(V2.5),通过无监督熵层次聚类、软件集成改进互信息法、熵聚类等方法进行数据挖掘,分析中医药基于芳香温通法治疗冠心病的中药组方规律。其中,用药频率≥10以上的中药有9味,处于前5位中药分别为冰片(28)、麝香(17)、苏合香(17)、川芎(15)、三七(13),将支持度个数及置信度分别设置为10、0.7,得到前3位药对频次是冰片、麝香(14),冰片、苏合香(14),苏合香、麝香(12),演化出核心药物组合14个,新处方7个。从中可以看出中医药基于芳香温通法治疗冠心病的同时兼以活血、行气化瘀,数据挖掘结果可为指导临床及开发新药提供参考。
Abstract:
Through the database retrieval of National Patent Bureau China National, China National Knowledge Infrastructure, filtering out 56 Chinese patent medicines and traditional Chinese medicine formula based on aromatherapy method the treatment of coronary heart disease and into the auxiliary system of Traditional Chinese medicine inheritance platform software(V2.5), adopted the improved mutual information method of software integration, entropy clustering of complex systems, and unsupervised entropy hierarchical clustering and other unsupervised data mining methods, and analysed the law of traditional Chinese medicine prescription. Among them, the frequency of use is greater than 10, 9 Chinese herb, is ranked in the top four borneol(28), musk(17), storax(17), rhizome chuanxiong(15), set support number 10 and confidence 0.7, reach the top three drugs on frequenc of borneol, musk(14), borneol, storax(14), storax, musk(12), as can be seen aromatherapy method of the treatment of coronary heart disease and at the same time with activating blood, qi and blood circulation, and can get the core evolution drug combination 14, seven new prescription, The data mining results can provide reference for clinical guidance and the development of new drugs。

参考文献/References

[1] 钟赣生. 中药学[M]. 北京:中国中医药出版社,2009:531,641.
[2] 蒋荣飞,杨志华,刘琰,等. 基于数据挖掘分析方文岩治疗乳腺癌用药组方规律[J]. 云南中医学院学报,2019,42(5):75-80.
[3] 李晓明. 麝香心脑通治疗冠心病30例疗效观察[J]. 中成药,2001,23(5):387-388.
[4] 华先平,詹艳,李梓香,等. 对慢性心力衰竭病人心功能的影响[J]. 中西医结合心脑血管病杂志,2011,9(2):143-145.
[5] 李文兵. 长期服用麝香保心丸治疗冠心病临床疗效分析[J]. 世界最新医学信息文摘,2019,19(11):131.
[6] 马堃,张金艳,李贻奎,等. 冠心苏合丸系列组方的比较药理学研究[J]. 中国中药杂志,2006,31(16):1353-1357.
[7] 王宇,芶定芬. 苏合香抗心肌缺血模型大鼠的疗效及剂量关系[J]. 中医学报,2019,34(10):2157-2163.
[8] 程雷玉. 丹参伍川芎对冠心病患者血液流变学的作用研究[J]. 中西医结合心血管病电子杂志,2018,6(35):157-158.
[9] 何天竺,辛宇,宋岩,等. 丹参-檀香配伍提取物对异丙肾上腺素诱发小鼠心肌缺血损伤的保护作用[J]. 吉林农业大学学报,2019,41(2):192-198.
[10] DU Y,GE Y,XU Z,et al. Hypoxia-inducible factor 1 alpha(HIF-1α)/vascular endothelial growth factor (VEGF)pathway participates in angiogenesis of myocardial infarction in muscone-treated mice:preliminary study[J]. Med Sci Monit,2018,24:8870-8877.
[11] WANG X,MENG H,CHEN P,et al. Beneficial effects of muscone on cardiac remodeling in a mouse model of myocardial infarction[J]. Int J Mol Med,2014,34(1):103-111.
[12] HUANG W,YANG Y,ZENG Z,et a. Effect of Salvia miltiorrhiza and ligustrazine injection on myocardial ischemia/reperfusion and hypoxia/reoxygenation injury[J]. Mol Med Rep,2016,14(5):4537-4544.
[13] 刘访遥,袁娜,王平. 川芎嗪对急性心肌梗死大鼠保护作用及机制[J]. 中国公共卫生,2019,35(9):1229-1234.
[14] WU P,DU Y,XU Z,et al. Protective effects of sodium tanshinone IIA sulfonate on cardiac function after myocardial infarction in mice[J]. Am J Transl Res,2019,11(1):351-360.
[15] 潘芸芸. 三七皂苷R1及Pim-2在H2O2诱导的心肌细胞损伤中的作用机制研究[D]. 广州:南方医科大学,2013.
[16] 高莹,杨积武,王艳春,等. 人参皂苷Re对大鼠心肌缺血再灌注细胞凋亡及Caspase-3的影响[J]. 辽宁中医药大学学报,2011,13(2):123-124.
[17] 孟红旭,姚明江,刘建勋. 人参皂苷Re对大鼠心室肌细胞钠、钾离子通道的影响[J]. 世界中医药,2013,8(10):1147-1149.
[18] WANG Q W,YU X F,XU H L,et al. Ginsenoside Re attenuates isoproterenol-induced myocardial injury in rats[J]. Evid Based Complement Alternat Med,2018,2018:8637134.
[19] CHEN S,LIU J,LIU X,et al. Panax notoginseng saponins inhibit ischemia-induc -ed apoptosis by activating PI3K/Akt pathway in cardiomyocytes[J]. J Ethnopharmacol,2011,137(1):263-270.

备注/Memo

备注/Memo:
收稿日期: 2019 - 12- 05
* 基金项目: 国家自然科学基金青年科学基金项目(81903839)
第一作者简介: 闫海峰(1987-),男,在读博士研究生,研究方向:中医药防治冠心病、心力衰竭。
△通信作者: 王淑萍,E-mail:wangshuping10 @163.com
更新日期/Last Update: 2020-06-30