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柴胡加龙骨牡蛎汤治疗冠心病并焦虑状态疗效的Meta分析(PDF)

《云南中医学院学报》[ISSN:1000-2723/CN:53-1048/R]

期数:
2020年03期
页码:
34-40
栏目:
临床研究
出版日期:
2020-11-15

文章信息/Info

Title:
Meta-analysis of the Therapeutic Effect of Bupleurum Falcatum Plus Dragon Boneand Oyster Shell Decoction on Coronary Heart Disease with Anxiety State
作者:
成雅1王海芳1袁瑞华2何锐1曹语1董静3刘勤社1△
1. 陕西中医药大学,陕西省中西医结合心血管病防治重点实验室,咸阳市中西医结合心血管病防治重点实验室,陕西 西安 712046;2. 陕西中医药大学真实世界研究院,陕西 西安 712046;3. 陕西中医药大学第二附属医院心内科,陕西 西安 712000
Author(s):
CHENG Ya1 WANG Haifang1 YUAN Ruihua2 HE Rui1 CAO Yu1 DONG Jing3 LIU Qinshe1
1. Shaanxi Key Laboratory of Integrated Traditional and Western Medicine for Prevention and Treatment of Cardiovascular Diseases, Xian Yang Key Laboratory of Integrated Traditional and Western Medicine for Prevention and Treatment of Cardiovascular Diseases, Shaanxi University of Traditional Chinese Medicine, Xi’an 712046, China; 2. Real World Clinical Research Institute, Shaanxi University of Traditional Chinese Medicine, Xi’an 712046, China;
关键词:
柴胡加龙骨牡蛎汤冠心病焦虑疗效Meta分析
Keywords:
Bupleurum falcatum plus dragon bone and oyster shell decoction coronary heart disease anxiety therapeutic effect Meta-analysis
分类号:
R259
DOI:
10.19288/j.cnki.issn.1000-2723.2020.03.007
文献标识码:
A
摘要:
目的 系统评价柴胡加龙骨牡蛎汤(CHJLGMLT)治疗冠心病并焦虑状态的临床疗效。方法 全面检索PubMed、EMbase、中国知网、VIP、WANFANG等数据库中CHJLGMLT治疗冠心病并焦虑状态的临床随机对照试验(randomized controlled trial,RCT),时限为建库至2020年5月,经过筛查、质量评估(Cochrane评价)将纳入文献的数据提取整理,利用RevMan5.3软件进行Meta分析。结果 最终纳入8篇文献。Meta分析结果显示:CHJLGMLT联合西药(冠心病基础用药及抗焦虑药)可有效改善患者的焦虑状态,降低焦虑量表评分[HAMA评分MD= -4.06,95% CI (-4.94,-3.18),P<0.000 01;SAS评分MD=-5.45,95% CI (-6.47,-4.43),P<0.000 01];CHJLGMLT联合西药组心绞痛疗效明显高于西药组[OR=5.16,95% CI (2.68,9.94),P<0.000 01]、躯体活动受限明显改善(西雅图心绞痛评分量表)[MD=11.54,95%CI(8.15,14.93),P<0.000 01]、中医症状积分明显降低[MD=-2.29,95%CI (-2.57,-2.01),P<0.000 01]。结论 CHJLGMLT联合西药较单纯西药可更有效改善冠心病患者的焦虑状态、心绞痛症状、躯体活动受限程度及中医症状。
Abstract:
Objective To systematically evaluate the clinical efficacy of bupleurum falcatum plus dragon bone and oyster shell decoction(CHJLGMLT) in the treatment of coronary heart disease with anxiety. Methods Comprehensive retrieval was performed for the clinical randomized controlled trials(RCTS) for CHJLGMLT in coronary heart disease with anxiety in databases like PubMed, EMbase, CNKI, VIP, WANFANG, etc., the search time is from database creation to May 2020. By screening and quality assessment(Cochrane evaluation), the data of the included literature were extracted and sorted out. Finally, the RevMan 5.3 software was employed for Meta-analysis. Results 8 relevant literatures were included in this study. The results of meta-analysis showed: CHJLGMLT combined with western medicine(coronary heart disease basic medicine and anti-anxiety drugs) was significantly better than western medicine group in imroving anxiety[HAMA score MD=-4.06,95% CI (-4.94,-3.18), P<0.000 01; SAS score MD=-5.45, 95%CI(-6.47,-4.43), P<0.000 01]; The clinical efficacy of angina pectoris was significantly better than that of western medicine group[OR=5.16, 95% CI(2.68, 9.94), P<0.000 01], Significant improvement of restricted physical activity(Seattle Angina scale)[MD = 11.54, 95% CI(8.15, 14.93), P<0.000 01], The traditional Chinese medicine symptom score was significantly lower [MD=-2.29, 95% CI (-2.57, -2.01), P<0.000 01]. Conclusion CHJLGMLT combined with western medicine can more effectively improve the anxiety state, angina symptoms, the degree of physical activity restriction,as well as the traditional Chinese medicine symptoms.

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备注/Memo

备注/Memo:
收稿日期: 2020 - 05- 08 基金项目: 国家自然科学基金面上项目(81573823);陕西省中医管理局资助项目(2019-ZZ-JC025);陕西中医药大学 第二附属医院学科创新团队项目(2020XKTD-B02) 第一作者简介: 成雅(1994-),女,在读硕士研究生,研究方向:中西医结合心血管病防治。 △通信作者: 刘勤社,E-mail:lqsspph@126.com
更新日期/Last Update: 2020-11-15