类风湿关节炎合并肺间质纤维化患者证候特征及影响因素分析*
作者:
作者单位:

(1. 云南中医药大学第一临床医学院,云南 昆明650021;2. 云南中医药大学第一附属医院,云南 昆明 650021)

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R255.6

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收稿日期: 2022 - 07- 18
基金项目: 云南省中医(风湿病)临床医学研究中心项目(202102AA310006);国家中医药管理局国家中医(类风湿关节炎)临床研究基地建设项目(国中医药科技函〔2018〕131号);云南省科技厅云南中医学院应用基础研究联合专项[2019FF002(-031),2019FF002(-082)];云财社〔2022〕118号云南省高层次中医药后备人才培养项目
第一作者简介: 孟凡雨(1997-),女,在读硕士研究生,研究方向:中医内科学风湿免疫方向。
通信作者: 彭江云,E-mail: pengjiangyun@126.com


Characterization of Symptoms and Factors Affecting Patients with Rheumatoid Arthritis Combined with Interstitial Lung Disease
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Affiliation:

(1. The First Clinical Medical College, Yunnan University of Chinese Medicine, Kunming 650021, China;2. The First Affiliated Hospital, Yunnan University of Chinese Medicine, Kunming 650021, China)

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    摘要:

    目的分析类风湿关节炎合并肺间质纤维化(RA-IPF)的中医证候特征及其相关影响因素。方法 采用病例对照的研究方法,通过电子病历系统搜集RA患者的基本信息、实验室指标、证候分型等临床资料,比较RA-IPF患者与单纯RA患者之间存在的差异,并分析RA-IPF的相关影响因素。结果 在2 788例RA患者中并发IPF者115例。与单纯RA相比,RA-IPF患者男性比例较多、年龄较大、血沉(ESR)加快、血D-二聚体增多、血RF-IgA升高、RF-IgM升高、RF-IgG升高、抗U1-RNP抗体升高、抗Jo-1抗体升高。结论 RA-IPF可能与患者的性别、年龄、ESR、D-二聚体、RF-IgA、RF-IgM、RF-IgG、抗U1-RNP抗体、抗Jo-1抗体有关;高龄是RA合并IPF的危险因素。

    Abstract:

    Objective To analyze the TCM syndromic features of RA-IPF and related influence factors. Methods A case-control study was used to collect clinical data such as basic information, laboratory indices and evidence typing of RA patients through the electronic medical record system. The differences of factors between RA-IPF and RA patients alone were analyzed and the main influence factors associated with RA-IPF were screened out. Results Among the 2 788 patients with RA, there were 115 patients with concurrent IPF. According to the results collected, RA-IPF patients were more likely men who were with older age, faster ESR, higher D-dimer, higher RF-IgA, higher RF-IgM, higher RF-IgG, higher anti-U1-RNP antibodies and higher anti-Jo-1 antibodies(P<0.05). Conclusion RA-IPF may be related to patients’ gender, age, ESR, D-dimer, RF-IgA, RF-IgM, RF-IgG, anti-U1-RNP antibodies, and anti-Jo-1 antibodies. An advanced age is a risk factor for RA-IPF.

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