A total of 241 TCM prescriptions for treating chronic cerebral circulation insufficiency issued by professor Lyu Guangrong from June 2017 to April 2021 were collected, which included a total of 180 flavors of traditional Chinese medicine after standardization. Inputting the data into Excel form, IBM SPSS Statistics 26 was used for frequency and systematic cluster analysis while IBM SPSS Modeler 18.0 for association rules. Finally, high prescription frequency of traditional Chinese medicine is mainly licorice, white, tangerine peel, barbary wolfberry, chrysanthemum, poria cocos, astragalus, et al. Five meaningful traditional Chinese medicine combinations were obtained after systematic cluster analysis.